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New study

Investigation of bariatric surgery on NAFLD in diabetics

Investigators to study the effect of low carbohydrate diet given for a month prior bariatric surgery on liver steatosis

Researchers at Sheba Medical Center, Israel, are investigating the effect of weight loss rate on liver steatosis, steatohepatitis and fibrosis at different stages before and after roux-en-y gastric bypass or sleeve gastrectomy in 30 diabetic patients.

In addition, the investigators are to study the effect of low carbohydrate diet given for a month prior bariatric surgery on liver steatosis and will examine to the short-term effect of bariatric surgery on gastric cholecystokinin levels before and ten days after the bariatric surgery.

The “Impact of Bariatric Surgery on Nonalcoholic Fatty Liver Disease in Diabetic Patients: Pre- and Post-Surgical Evaluation Utilizing Non-invasive Measures” study will report the change from baseline liver steatosis, steatohepatitis and fibrosis at baseline and six, 12, 24 and 48 weeks after surgery.

Changes will be identified by blood tests of liver functions: Alanine transaminase, Aspartate transaminase, Alkaline Phosphatase, gamma-glutamyl transpeptidase, ferritin, prothrombin-time, international normalised ratio, Total/Direct Bilirubin, Albumin, uric acid), lipids profile (total cholesterol, triglycerides, HDL, LDL) and diabetes biomarkers (insulin, glucose, HbA1c).

They will also measure adiponectin and tumor necrosis factor (only at baseline and at 12, 24 and 48 weeks after surgery), liver fibrosis by means of elastography (only at baseline and at 24 and 48 weeks after surgery) and grade liver damage (only at baseline and at 12, 24 and 48 weeks after surgery).

The researchers will also report on change of liver steatosis following a low carbohydrates diet at time of surgery compared to baseline.

Principal Investigator, Professor Ziv Ben-Ari from Sheba Medical Center, expects to complete the study in July 2014.

 

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