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09:42 10/02/14 | Owen Haskins | Editor in chief, Bariatric News

Just in case you missed any news last month, these were the 10 most read articles on bariatricnews.net in January 2014 including the latest research, product & industry news, policy news and more...

Insulin secretion post-bypass may explain T2DM resolution

Insulin-producing beta cells increase in number and performance after the gastric bypass and could explain why patients recover from their type 2 diabetes within days of surgery before any weight loss has taken place, researchers from Lund University Diabetes Centre in Sweden claim...(more)

UK launch for Obalon’s swallowable balloon system

The world’s first ‘swallowable’ weight loss balloon, the Obalon gastric balloon system, has been launched in the UK. Exclusively distributed by Purple Surgical in partnership with Spire Healthcare, the system can be placed in just five minutes by swallowing a small capsule, the size of a large vitamin pill...(more)

Banding patients must adhere to nutritional advice

Gastric banding patients do not meet recommended daily requirements for important nutrients such as protein, vitamin D and calcium, despite receiving nutritional counselling over a three-month period, according to the outcomes of a study by UT Southwestern Medical Center researchers...(more)

Study: BIORING is comparable to LAPBAND

The adjustable BIORING gastric ring (Cousin Biotech) is as safe and effective as the LAPBAND ring (Allergan), according to the results from a randomised study1 presented at the French society of obesity surgery (SOFFCO), in June 2013, realized by Pr Chevallier...(more)

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11:49 06/02/14 | Owen Haskins | Editor in chief, Bariatric News

The January-February 2014 (Volume 10, Issue 1) issue of Surgery for Obesity and Related Diseases is out now featuring literature reviews, case reports and comments. Here are some of the highlights:

Changes in post-prandial glucose and pancreatic hormones, and steady-state insulin and free fatty acids after gastric bypass surgery.
This study compared the changes of glucose and pancreatic hormones [C-peptide, glucagon, and pancreatic polypeptide (PP)] during a meal tolerance test (MTT) and steady-state insulin and free fatty acid (FFA) concentrations during euglycemic–hyperinsulinemic clamp 14 days and 6 months after RYGB in morbidly obese nondiabetic patients. the researcher studied two gropus at baseline and at 14 days: the RYGB followed by caloric restriction group (RYGB, n = 12) and the equivalent caloric restriction alone group (Diet, n = 10), to control for energy intake and weight loss. The RYGB group was studied again at 6 months to assess the changes after substantial weight loss. During MTT, the early and overall changes in glucose and pancreatic hormone concentrations were determined, and during the clamp, steady-state insulin and FFA concentrations were assessed. they found that in morbidly obese nondiabetic patients, RYGB produces early changes in postmeal glucose, C-peptide, glucagon, and PP responses, and it appears to enhance insulin clearance early after RYGB and improve insulin sensitivity in adipose tissue at 6 months postsurgery.

Twelve-year results for revisional gastric bypass after failed restrictive surgery in 131 patients.
This paper examined long-term results of rRYGB from 131 patients who had RYGB  at 2 university hospitals and completed questionnaire regarding their current status. The questionnaire was returned by 131 patients (75% follow-up rate, 66 VBG and 65 GB patients). Blood samples were obtained and medical charts studied. The reason for conversion was mainly unsatisfactory weight loss among the VBG patients and intolerable side effects among GB patients. they report that the overall result was satisfactory for 74% of the patients. Only 21% of the patients adhered to the recommendation of lifelong multivitamin supplements while 76% took vitamin B12. nevertheless, micronutrient deficiencies were frequent.

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02:31 28/01/14 | Anonymous (not verified) |

In a recent paper, Australian researchers reported that bariatric surgery may be an effective diabetes prevention strategy for paitents with impaired fasting glucose. Here, co-author of the study, Professor Paul O'Brien, discusses the possible implications of the findings...

Prevention is better than cure. Yet, in medicine, we get so few opportunities to truly prevent new diseases. This study indicates such an opportunity. And it is a big one, the prevention of diabetes!

The International Diabetes Federation estimates 382 million people are living with diabetes today. Diabetes contributes heavily to the illnesses, mortality and healthcare costs of the community. The number of people with diabetes continues to grow rapidly, an epidemic that is linked to the rising rates of obesity. Diabesity is a real entity.

With prediabetes you are in the diabetes waiting room. The Diabetes Prevention Program1 informs us how soon you will be called. They had a control group with prediabetes, with a mean BMI of 34 and no treatment. The group showed an 11% likelihood of progressing to diabetes each year.  So, if you are obese and have prediabetes today, you have a better than 50% chance of having diabetes within 5 years. Then you will be subject to all the consequences of that disease.

Weight loss will reduce your risk markedly.

There were two key findings arising from the prediabetes study which we have just published.

The first was the profound effect of weight loss on the risk of progressing to diabetes. We performed gastric banding on 281 people with prediabetes and a mean BMI of 46. We then followed them for a mean of 4 years.  We compared them with a group of people with prediabetes and a mean BMI of 34 who did not have weight loss. For the weight loss group, there was a hazard ratio of 0.25, a 75% reduction in the relative risk of progressing to diabetes. 

It probably doesn’t matter how the weight loss is achieved. In this study we used gastric banding. Others have used lifestyle programs1 or other forms of bariatric surgery2.

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08:35 20/01/14 | Owen Haskins | Editor in chief, Bariatric News

This week we report on papers from the Journal of Hepatology, the American Journal of Physiology - Regulatory, Integrative, and Comparative Physiology, the Journal of Laparoendoscopic & Advanced Surgical Techniques, the Journal of Diabetes and the International Journal of Surgery Case Reports…

Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients.

Published in the Journal of Hepatology, the study investigated the effects of bariatric surgery on hepatic insulin sensitivity. Twenty-three morbidly obese (nine diabetic and fourteen non-diabetic) patients and ten healthy, lean control subjects were studied using PET to assess hepatic glucose uptake in the fasting state and during euglycaemic hyperinsulinemia. Obese patients were studied before bariatric surgery (either sleeve gastrectomy or Roux-en-Y gastric bypass) and six months after surgery. The researchers concluded that  surgery leads to a significant improvement in hepatic insulin sensitivity: as insulin-stimulated hepatic glucose uptake was improved and endogenous glucose production reduced when measured, six-months, after surgery. Abstract

GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents.

Featured in the American Journal of Physiology - Regulatory, Integrative, and Comparative Physiology, the researchers examined complementary pharmacological and genetic loss-of-function approaches to test the role of increased signalling of GLP-1 and PYY in high-fat diet-induced obese rodents. The reported that there was no evidence that either gut hormone an important role in the specific mechanisms by which RYGB rats settle at a lower body weight. They state that the beneficial effects of bariatric surgeries are expressed through complex mechanisms that require combination approaches for their identification. Abstract

Single-Incision Laparoscopic Sleeve Gastrectomy Versus Multiport Laparoscopic Sleeve Gastrectomy: Analysis of 80 Cases in a Single Center.

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