Leptin plays a role in the development of obesity at a young age

Young children of African ancestry are more at risk of developing obesity if they possess a genetic variant that reduces their ability to produce the hormone leptin, according to a study, ‘Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity’, published in the journal Diabetes. Interestingly, adults with the variant do not have the same risk, suggesting that leptin plays a role in the development of obesity at a young age but the obesity does not continue into adulthood.

High-protein total diet replacements a promising strategy to combat obesity

In a study comparing the impact of a high-protein total diet replacement (HP-TDR) to that of a control diet (CON), a typical North American diet, researchers led by Camila Oliveira, a doctoral student at the University of Alberta, reported that a HP-TDR led to higher total energy expenditure (EE), increased fat oxidation and negative fat balance. These results suggest that a HP-TDR may promote fat loss compared with a conventional isocaloric diet.

CT scan is predictive of internal herniation if mesenteric defect is closed

A computer tomography (CT) scan can be predictive for the diagnosis of internal herniation (IH), if the mesenteric defect is closed following Roux-en-Y gastric bypass (RYGB), however, the diagnostic accuracy of a CT scan is not useful in a patient with open mesenteric defect, according to researchers from Leiden University Medical Center, Leiden and the Dutch Obesity Clinic West & LUMC, The Hague, The Netherlands. The findings, ‘Internal Herniation Incidence After RYGB and the Predictive Ability of a CT Scan as a Diagnostic Tool’, were published in Obesity Surgery.

The experience of Israeli bariatric surgeons during COVID

Bariatric surgeons in Israel have reported experiencing a variance in their reactions during the COVID-19 pandemic, according to the results from an anonymous web-based questionnaire sent to all active bariatric surgeons (n=63) in Israel that sought to portray the practices and attitudes of Israeli bariatric surgeons in the first phase of the pandemic.

People under 50 with overweight and obesity at greater risk for severe COVID-19

Being under 50 years of age does not protect against the dangers of COVID-19 if you are overweight, according to a study from UT Southwestern (UTSW). While all adults who are overweight or have obesity are at greater risk for serious complications from the disease, the link is strongest for those age 50 and under. More than 42 percent of American adults have obesity, according to the Centers for Disease Control and Prevention, and approximately another 30 percent are overweight.

Five preoperative characteristics could predict success of RYGB

Researchers from Brazil have developed and validated an accurate predictive model that comprises the sum of five outcome variables to predict success of Roux-en-Y gastric bypass (RYGB) based exclusively on patients’ preoperative characteristics. The findings could be used to prioritise patients with the best indication for the procedure and incorporated in the public health system as a support tool in the decision-making process.

Pyruvate kinase enzyme could be new target for treating T2DM

Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete, which could provide a promising new target to develop drugs for boosting insulin production in people with T2DM. In two papers published in Cell Metabolism, scientists from the University of Wisconsin-Madison and their colleagues point to an overlooked enzyme known as pyruvate kinase as the primary way pancreatic beta cells sense sugar levels and release the appropriate amount of insulin.

Majority of T2DM patients are at high risk of a fatal heart attack or stroke

Preventing heart attacks and strokes in type 2 diabetes patients managed in primary care should be an urgent priority, according to the study, ‘Half of patients with type 2 diabetes mellitus are at very high cardiovascular risk according to the 2019 ESC/EASD categories: data from a large Mediterranean population’, published on World Diabetes Day in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).

LOSEIT: TBE demonstrates sustained weight loss at 12 months

A single-blind, sham procedure randomised trial of transcatheter bariatric embolotherapy (TBE) of the left gastric artery (LGA) in patients with obesity has shown that the procedure is well-tolerated and resulted in effective weight loss at six-month follow-up, compared with the sham control, and the weight loss was sustained at 12 months.

Lifestyle, diet and physical activity changes halves the risk of T2DM

Providing support to help people with prediabetes make small changes to their lifestyle, diet and physical activity can almost halve the risk of developing type 2 diabetes, according the results of the Norfolk Diabetes Prevention Study (NDPS) the largest diabetes prevention research study in the world in the last 30 years.

Allurion releases new clinical data on the Elipse Balloon

Allurion Technologies has announced new clinical data from two studies on the Elipse Balloon at ObesityWeek 2020. The Allurion Program features the Elipse Balloon, the world’s first and only procedureless weight loss device. The balloon is designed to remain in the stomach for four months and is paired with a Bluetooth connected scale and Allurion smartphone app and a supervised nutritional programme.

Magnetic sphincter augmentation with LINX System effective GERD treatment

The LINX Reflux Management System provides effective long-term control of gastroesophageal reflux disease (GERD) and eliminates the need for daily reflux medications in 79% of patients according to the study, ‘Six to 12-year outcomes of magnetic sphincter augmentation (MSA) for gastroesophageal reflux disease’, published in the journal Nature Scientific Reports.

Banded Sleeve Gastrectomy: Is there a method to this madness?

On 29th September 2020, the International Bariatric Club (IBC) hosted the 16th iteration in its series of IBC ‘Oxford Hot Topics in Surgery’ webinars, entitled ‘Banded sleeve gastrectomy - Is there a method to this madness?’. The webinar featured presentations from world renowned experts in banded sleeve gastrectomy including Professors Phil Schauer (USA) and Jodok Fink (Germany), and Dr Paolo Gentileschi (Italy), as well as a video presentation by Dr Mohit Bhandari (India).

Simultaneous robotic kidney transplant and bariatric surgery is safe

Kidney transplants are frequently denied to patients with obesity, partly due to an increased risk of surgical complications, particularly infections. Now surgeons at University of Illinois Chicago Heath who have pioneered the use of robotic-assisted surgery has shown that robotic-assisted kidney transplant and bariatric surgery can be performed safely to successfully reduce surgical complications.