There is growing evidence that adipose tissue plays a key role in the aggravation of COVID-19. One of the theories under investigation is that fat cells (adipocytes) act as a reservoir for SARS-CoV-2 and increase viral load in obese or overweight individuals. Scientists also suspect that during infection, fat cells release substances into the bloodstream that boost the inflammatory reaction triggered by the virus in the organism.
More than half of men (55%) and two thirds (65%) of women currently aged 20 years in India will likely develop diabetes in their life time, with most of those cases (around 95%) likely to be T2DM, according to research by an international team from India, the UK and the US, led by Dr Shammi Luhar, Department of Public Health and Primary Care, University of Cambridge, UK.
Young children of African ancestry are more at risk of developing obesity if they possess a genetic variant that reduces their ability to produce the hormone leptin, according to a study, ‘Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity’, published in the journal Diabetes. Interestingly, adults with the variant do not have the same risk, suggesting that leptin plays a role in the development of obesity at a young age but the obesity does not continue into adulthood.
Researchers studying a group of UK healthcare workers discovered that non-white individuals recovering from COVID-19 displayed higher antibody levels than white individuals, with significantly greater levels observed in Asian individuals.
Patients with obesity who are over the age of 60 can lose an equivalent amount of weight as younger people using only lifestyle changes, according to a study from the University of Warwick and University Hospitals Coventry and Warwickshire (UHCW) NHS Trust, demonstrating that age is no barrier to losing weight.
In a study comparing the impact of a high-protein total diet replacement (HP-TDR) to that of a control diet (CON), a typical North American diet, researchers led by Camila Oliveira, a doctoral student at the University of Alberta, reported that a HP-TDR led to higher total energy expenditure (EE), increased fat oxidation and negative fat balance. These results suggest that a HP-TDR may promote fat loss compared with a conventional isocaloric diet.
A computer tomography (CT) scan can be predictive for the diagnosis of internal herniation (IH), if the mesenteric defect is closed following Roux-en-Y gastric bypass (RYGB), however, the diagnostic accuracy of a CT scan is not useful in a patient with open mesenteric defect, according to researchers from Leiden University Medical Center, Leiden and the Dutch Obesity Clinic West & LUMC, The Hague, The Netherlands. The findings, ‘Internal Herniation Incidence After RYGB and the Predictive Ability of a CT Scan as a Diagnostic Tool’, were published in Obesity Surgery.
Bariatric surgeons in Israel have reported experiencing a variance in their reactions during the COVID-19 pandemic, according to the results from an anonymous web-based questionnaire sent to all active bariatric surgeons (n=63) in Israel that sought to portray the practices and attitudes of Israeli bariatric surgeons in the first phase of the pandemic.
Researchers led by MedUni Vienna have discovered the signalling pathways responsible for the development of a valuable type of adipose tissue macrophage (ATM) in obesity, which prevents lipotoxicity, the process whereby fat molecules are deposited in non-adipose tissues.
Being under 50 years of age does not protect against the dangers of COVID-19 if you are overweight, according to a study from UT Southwestern (UTSW). While all adults who are overweight or have obesity are at greater risk for serious complications from the disease, the link is strongest for those age 50 and under. More than 42 percent of American adults have obesity, according to the Centers for Disease Control and Prevention, and approximately another 30 percent are overweight.
Researchers from Brazil have developed and validated an accurate predictive model that comprises the sum of five outcome variables to predict success of Roux-en-Y gastric bypass (RYGB) based exclusively on patients’ preoperative characteristics. The findings could be used to prioritise patients with the best indication for the procedure and incorporated in the public health system as a support tool in the decision-making process.
Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete, which could provide a promising new target to develop drugs for boosting insulin production in people with T2DM. In two papers published in Cell Metabolism, scientists from the University of Wisconsin-Madison and their colleagues point to an overlooked enzyme known as pyruvate kinase as the primary way pancreatic beta cells sense sugar levels and release the appropriate amount of insulin.
Preventing heart attacks and strokes in type 2 diabetes patients managed in primary care should be an urgent priority, according to the study, ‘Half of patients with type 2 diabetes mellitus are at very high cardiovascular risk according to the 2019 ESC/EASD categories: data from a large Mediterranean population’, published on World Diabetes Day in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).
A single-blind, sham procedure randomised trial of transcatheter bariatric embolotherapy (TBE) of the left gastric artery (LGA) in patients with obesity has shown that the procedure is well-tolerated and resulted in effective weight loss at six-month follow-up, compared with the sham control, and the weight loss was sustained at 12 months.
Providing support to help people with prediabetes make small changes to their lifestyle, diet and physical activity can almost halve the risk of developing type 2 diabetes, according the results of the Norfolk Diabetes Prevention Study (NDPS) the largest diabetes prevention research study in the world in the last 30 years.
Allurion Technologies has announced new clinical data from two studies on the Elipse Balloon at ObesityWeek 2020. The Allurion Program features the Elipse Balloon, the world’s first and only procedureless weight loss device. The balloon is designed to remain in the stomach for four months and is paired with a Bluetooth connected scale and Allurion smartphone app and a supervised nutritional programme.
The LINX Reflux Management System provides effective long-term control of gastroesophageal reflux disease (GERD) and eliminates the need for daily reflux medications in 79% of patients according to the study, ‘Six to 12-year outcomes of magnetic sphincter augmentation (MSA) for gastroesophageal reflux disease’, published in the journal Nature Scientific Reports.
On 29th September 2020, the International Bariatric Club (IBC) hosted the 16th iteration in its series of IBC ‘Oxford Hot Topics in Surgery’ webinars, entitled ‘Banded sleeve gastrectomy - Is there a method to this madness?’. The webinar featured presentations from world renowned experts in banded sleeve gastrectomy including Professors Phil Schauer (USA) and Jodok Fink (Germany), and Dr Paolo Gentileschi (Italy), as well as a video presentation by Dr Mohit Bhandari (India).
The standard approach of assessing long-term risk for atherosclerotic cardiovascular disease (ASCVD) works just as well for patients who are overweight as they do for patients at an optimal weight, according to a study by researchers from Yale and published in the JAMA Network Open.
Kidney transplants are frequently denied to patients with obesity, partly due to an increased risk of surgical complications, particularly infections. Now surgeons at University of Illinois Chicago Heath who have pioneered the use of robotic-assisted surgery has shown that robotic-assisted kidney transplant and bariatric surgery can be performed safely to successfully reduce surgical complications.
Reducing the level of body fat and waist size are linked to a lower risk of heart failure in patients with type 2 diabetes, according to a study led by UT Southwestern researchers. The findings, published in Circulation, suggest that all weight loss is not equal when it comes to mitigating the risk of heart disease.
Scientists from Indiana University School of Medicine, the University of Michigan and Case Western Reserve University have found that insulin has met an evolutionary cul-de-sac, limiting its ability to adapt to obesity and thereby rendering most people vulnerable to type 2 diabetes.
Synlogic has treated the first healthy volunteer in its Phase 1 study of the investigational Synthetic Biotic medicine SYNB8802 for the treatment of Enteric Hyperoxaluria (HOX). Enteric Hyperoxaluria is an acquired metabolic disorder caused by increased absorption of dietary oxalate, which is present in many healthy foods, making it almost impossible to control with diet alone.
MediSmart Technologies has announced the international launch of a new specialist bariatric range offering dynamic air mattresses, integrated hybrids, embedded hybrids, seating options and the ultra-low Bariatric Microcell Companion air mattress (this mattress can be retrofitted onto riser recliners).
The new bariatric range includes:
University of Oxford researchers have discovered that obesity can increase the chances of developing kidney disease. Funded by Kidney Research UK and the Medical Research Council, this study has found that fat all over the body increases risk, not just fat around the middle (abdominal fat) and suggests controlling weight could be a new way to manage kidney disease risk. This study, ‘Conventional and Genetic Evidence on the Association between Adiposity and CKD’, was published in the Journal of the American Society of Nephrology.
GI Windows Medical’s self-forming magnetic compression anastomosis device indicated for small bowel end to end anastomosis for ileostomy reversal or tissue resection, has been granted Breakthrough Device Designation by the FDA.
Timely post-operative lifestyle intervention could be useful for bariatric patients in helping them enhance and maintain better outcomes after bariatric surgery, according to researchers from the Evangelical Hospital ‘Villa Betania’ and the University of Naples ‘Parthenope’, in Naples, Italy. Specifically, they state that a multidisciplinary team of different professionals may be fundamental in order to guarantee the long-term effectiveness of the surgical intervention.
Researchers from Rijnstate ziekenhuis Arnhem, Arnhem, the Netherlands, are investigating whether the volumetric amount of spinal epidural lipomatosis (SEL) declines significantly in the lower spine after bariatric surgery. The observational study, ‘Spinal epidural lipomatosis before and after bariatric surgery’, is aiming to recruit 50 patients and compared the volume of SEL in bariatric patients before and after surgery and those patients with normal weight (BMI 20-25).
Revisional One Anastomosis/Mini-Gastric Bypass (OAGB/MGB) procedures after failed restrictive bariatric surgery (eg gastric lap band) is feasible and effective, according to a meta-analysis from 26 studies including 1,771 patients. The findings were reported in the paper, ‘One Anastomosis/Mini-Gastric Bypass (OAGB/MGB) as Revisional Surgery Following Primary Restrictive Bariatric Procedures: a Systematic Review and Meta-Analysis’, published in Obesity Surgery.
Bariatric News is sad to report that Professor Nicola Scopinaro, a true pioneer in Bariatric Surgery, has died at the age of 75. He was born on March 6, 1945, in Castagneto Carducci, a small village in the Province of Livorno in the Italian region Tuscany, located about 90 kilometres (56 miles) southwest of Florence. Professor Nicola Scopinaro was known by many as a great surgeon and innovator, a dedicated and hard worker, a teacher and mentor to several generations of surgeons, and as one of the fathers of modern bariatric surgery.
All adults with endocrine disorders should be tested for high cholesterol and triglycerides to evaluate their risk of heart attack or stroke, according to a Clinical Practice Guideline, ‘Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline, issued by the Endocrine Society and published in the Journal of Clinical Endocrinology & Metabolism.
Researchers from Brunel University London found that increasing weight is causally protective for breast and prostate cancer, according to researcher presented by Dr Hasnat Amin, a doctoral student at Brunel University London, who presented the results of the study at the American Society of Human Genetics 2020 Virtual Meeting.
Low levels of vitamin D during the first year of life are inversely associated with metabolic syndrome in adolescence - which is closely linked to obesity - according researchers at the University of Michigan. They reported that serum 25-hydroxyvitamin D [25(OH)D] at aged one is inversely associated with childhood BMI-for-age z-score (BMIZ), percentage body fat at age 16/17 years and a metabolic syndrome (MetS) score at age 16/17 years.
Although adolescents with obesity are choosing bariatric surgery as a way to lose a significant amount of weight, many of those with severe obesity, especially Hispanic and Black adolescents, are not being offered that treatment option. There findings were reported in a retrospective study, ‘Disparity Between United States Adolescent Class II and III Obesity Trends and Bariatric Surgery Utilization, 2015-2018’, published in Annals of Surgery by researchers at The University of Texas Health Science Center at Houston (UTHealth).
UC Berkeley Nutritional Sciences investigators have discovered that a microRNA (non-coding RNA that prevent genes from making proteins) is associated with energy storage and metabolic diseases such as obesity, insulin resistance and type 2 diabetes. The findings, ‘A MicroRNA Linking Human Positive Selection and Metabolic Disorders’, were published in Cell.
Swedish researchers at Karolinska Institutet and Danderyd Hospital, examining the risk of additional myocardial infarctions and early death in patients with severe obesity who undergo metabolic surgery following a myocardial event, have reported a lower risk of additional myocardial infarctions and improved survival that cannot be simply attributed to the loss of weight in this group of patients.
Scientists from across the globe will present the latest research in obesity science and medicine and related topics at the 38th Annual Meeting of The Obesity Society (TOS) at ObesityWeek Interactive. This online event will take place November 2–6, 2020 at www.obesityweek.org. On-demand materials and other elements of the interactive conference will remain available online through to December 31, 2020.
Researchers from Israel have reported both patients with obesity and healthcare professionals (HCPs) need to improve awareness regarding the physiologic basis and clinical management of obesity. Specifically, they noted that physicians need to improve how to approach weight and weight management discussions during patient consultations.
Body image is a mediating factor of depression in subgroup of laparoscopic sleeve gastrectomy (LSG) patients with poor psychological outcome, report researchers from the Medical University Hospital Tübingen, Tübingen and the University of Duisburg-Essen, Essen, Germany. They noted that the current preparation and aftercare regimes for patients that undergo bariatric surgery often focus on nutrition and physical activity, but hardly target psychological components, and interventions to improve body image should be incorporated into aftercare regimes.
Researchers from Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK, have redefined how the so-called gut microbiome operates and how our bodies coexist with some of the 100 trillion bacteria that make it up. The findings, ‘Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota’, were published in the journal Science, and could lead to new therapies for inflammatory bowel disease and people who've had portions of their bowels removed due to conditions like colon cancer and ulcerative colitis.
A study by Princeton University and Mpala Research Center, in Kenya, has found evidence for the ‘mismatch’ hypothesis when they found that obesity, diabetes and cardiovascular illnesses increased among whose diet changed from animal-based to carbohydrate-based. The mismatch hypothesis argues that our bodies have evolved and adapted to digest the foods that our ancestors ate and that human bodies will struggle and largely fail to metabolise a radically new set of foods.
Undertaking aerobic exercise prior to bariatric surgery in addition to standard medical care decreased the length of hospital stay in patients receiving bariatric surgery, compared to standard medical care alone, according to the outcomes of a small pilot trial by researchers from University of Virginia, Charlottesville, VA. The outcomes were featured in the paper, ‘Pre-operative aerobic exercise on metabolic health and surgical outcomes in patients receiving bariatric surgery: A pilot trial’, published in PLOS One.
Access to bariatric surgery should be increased as part of the main treatment considerations in women with obesity and polycystic ovarian syndrome (PCOS). The paper, ‘A Review of the Impact of Bariatric Surgery in Women With Polycystic Ovary Syndrome’, published in Cureus, led by California Institute of Behavioral Neurosciences & Psychology, Fairfield in the US, also recommends that additional research with better study designs are required in the future to investigate the relationship between PCOS and bariatric surgery.
Researchers at Ben-Gurion University of the Negev (BGU) have discovered a neural subnetwork of connected regions between the brain and gastric basal electric frequency that correlates with future weight loss based on connectivity patterns.
Vietnamese-American adults who did not have obesity were 60% more likely to have diabetes than those without obesity, non-Hispanic, White Americans, after accounting for age, sex, sociodemographic factors, smoking history and exercise level. Overall, only 9% of Vietnamese Americans with diabetes in the study had obesity. In comparison, half of all non-Hispanic White Americans with diabetes had obesity.
Researchers from Le Bonheur Children's Hospital and the University of Tennessee Health Science Center who are trying to determine the mechanisms underlying abnormal development of the enteric nervous system in Hirschsprung disease, have reported delineating interactions between migrating neural crest cells and the extracellular matrix in a model of Hirschsprung disease using a variety of in vitro and in vivo approaches.
According to the latest The Childhood Obesity Surveillance Initiative (COSI) in the Republic of Ireland (COSI) survey - carried out as part of the World Health Organization and European Union's effort to measure weight trends in young children - obesity rates in primary school children across Ireland are decreasing. The prevalence of obesity in children aged six to ten has continued to go down year on year.
Too much abdominal fat amongst the Mexican Americans population predicts the beginning of atherosclerosis, but researchers at McGovern Medical School at the University of Texas Health Science Center at Houston, TX, report that this is only true for those who were born in the US.
People who have had bariatric surgery live three years longer, on average, than those given conventional treatment for their obesity, a University of Gothenburg study has reported. Compared with the general population, however, both groups' excess mortality is higher.
The probability that a person with obesity will develop severe COVID-19 is high regardless of age, sex, ethnicity and the presence of co-morbidities such as diabetes, high blood pressure, and heart or lung disease, according to a Brazilian study.
Limiting the hours of television advertising for foods and beverages high in fat, sugar and salt (HFSS) could make a meaningful contribution to reducing childhood obesity, according to a study published by Oliver Mytton of the University of Cambridge, UK, and colleagues.
People with eating disorders are 12 times more likely to be preoccupied with perceived flaws in their physical appearance than those without, according to researchers from Anglia Ruskin University (ARU). The study authors claim their research provides more evidence of the complex relationship that exists between body dysmorphic disorder (BDD) and eating disorders. Furthermore, they recommended that practitioners working with BDD subjects should screen for eating disorders due to the high morbidity associated with eating disorders.
Duodenal mucosal resurfacing (DMR) endoscopic therapeutic procedure may lead to the discontinuation of insulin treatment in a significant number of people with type 2 diabetes, according to research presented at UEG Week 2020 Virtual.
Bariatric surgery significantly cuts the risk of developing pancreatic cancer in people with obesity and diabetes, a new 20-year analysis has found. The study, presented at UEG Week 2020 Virtual, analysed 1,435,350 patients with concurrent diabetes and obesity over a 20-year period.
Parathyroid axis monitoring could benefit patients who at high-risk of hyperparathyroidism after bariatric surgery, according to researcher from the US, who noted that patients with renal failure, hypertension and anaemia would likely benefit from earlier follow-up with parathyroid axis monitoring (outpatient monitoring of calcium, vitamin D and PTH levels). They also reported that monitoring is likely most beneficial for patients younger than 45 years of age.
Bariatric surgery could be effective in improving male’s sexual (erectile) function in patients with obesity, according to Chinese researchers, however, due to the limited number of studies evaluating this topic, the authors noted that additional studies are required to confirm their findings. The paper, ‘The relationships between bariatric surgery and sexual function: current evidence based medicine’, was published in BMC Urology.
The High Mobility Group Box-1 (HMGB1) molecule is higher in the blood of younger black adults than whites, females than males and increases with weight and age, researchers report in the first large, longitudinal study associating circulating HMGB1 levels with obesity, inflammation promoters and early indicators of cardiovascular risk in humans.
The British Obesity and Metabolic Surgery Society (BOMSS) and dendrite Clinical Systems have published the Third National Bariatric Surgery Registry (NBSR) Report that outlines the safety and effectiveness of bariatric and metabolic surgery. This latest report examines data from 19,104 Roux-en-Y gastric bypass (RYGB) procedures, 13,841 sleeve gastrectomy (SG), 4,499 gastric bands (GB) and 1,515 One Anastomosis Gastric Bypasses (OAGB) performed between 2013 and 2018. Mirroring global trends, SG replaced RYGB to become the commonest bariatric procedure in the UK in 2018.
An international group of global experts including anaesthetists, surgeons and other healthcare professionals have come together to publish a consensus statement on the prevention of opioid-related harm in adult surgical patients. The consensus statement, ‘An international multidisciplinary consensus statement on the prevention of opioid‐related harm in adult surgical patients’, was published in Anaesthesia (a journal of the Association of Anaesthetists).
There are similar overall early and late complication rates between primary and revisional robotically-assisted laparoscopic Roux-en-Y gastric bypass (RYGB), with higher rates of gastrojejunal strictures and readmissions for oral intolerance in the revisional group, according to a study by researchers from Texas. The results were reported in the paper, ‘Outcomes of primary versus revisional robotically assisted laparoscopic Roux-en-Y gastric bypass: a multicenter analysis of ten-year experience’, published online in Surgical Endoscopy.
A study by researchers at McGill University has identified polycystic ovary syndrome (PCOS) as an independent risk factor for gestational diabetes (GDM), gestational hypertension (GHTN) and preeclampsia (PEC) of pregnancy. After controlling for all potential confounding effects, women with PCOS were at a two-fold higher risk of developing GDM, a 50% increased risk for the development of GHTN and a 30% increased risk of developing PEC, compared to women without PCOS.
Researchers from the University of Oregon’s Prevention Science Institute have developed a complicated model to determine the roles nature and nurture play when it comes to children and their weight. Nature – genetics - plays a larger role, but nurture is also substantially responsible for whether a child has obesity.
Researchers at the University College London and University College London Hospitals NHS Foundation Trust), London, UK, have found that the vast majority of participants with new onset loss of smell were seropositive for SARS-CoV-2 antibodies, and this acute loss of sense of smell needs to be considered globally as a criterion for self-isolation, testing and contact tracing in order to contain the spread of COVID-19. Indeed, the authors noted that the loss of a sense of smell may be a more reliable indicator of Covid-19 than cough or fever.
In a survey of physicians, certified by the American Board of Obesity Medicine (ABOM), by researchers at Johns Hopkins Medicine, has found that these practitioners commonly offer key services supported by scientific research and clinical trials. This suggests that primary care clinicians can be increasingly confident that their patients will receive this ‘evidence-based care’ when referred to an obesity specialist.
The European Association for the Study of Obesity (EASO) and the European Coalition for People Living with Obesity (ECPO) are urging patients to continue their treatment for obesity and not to let it lapse because of fears about COVID-19. The organisations are very concerned that people seeking treatment for overweight and obesity have either postponed or stopped seeking medical advice because of fears they may be putting themselves at risk.
An editorial accompanying a study published in the Journal of the American College of Cardiology is bringing attention to the underappreciated and often overlooked issue of malnutrition among people with obesity. Malnutrition is defined as faulty nutrition due to inadequate or unbalanced intake of nutrients.
Some people are at higher risk of developing obesity because they possess genetic variants that affect how the brain processes sensory information and regulates feeding and behaviour, according to findings from scientists at the University of Copenhagen. The outcomes support a growing body of evidence that obesity is a disease whose roots are in the brain.
People who are severely overweight are less likely to be able to re-wire their brains and find new neural pathways, a discovery that has significant implications for people recovering from a stroke or brain injury. In the paper, ‘Obesity is Associated with Reduced Plasticity of the Human Motor Cortex’, published in Brain Sciences, researchers from UniSA and Deakin University report0 that brain plasticity is impaired in people with obesity, making it less likely that they can learn new tasks or remember things.
Excess fat stored around the abdomen (central fatness) is associated with a higher risk of early death from any cause, regardless of overall body fat, whereas larger hips and thighs are associated with a lower risk, according to researchers from Iran and Canada. The results suggest that measuring central fatness may be a more reliable indicator of risk of death from excess weight and could be used alongside body mass index to help determine the risk of premature death.
Five to 10 percent of surgically induced weight loss is associated with improved life expectancy and cardiovascular health compared with about 20 percent weight loss is necessary to observe similar benefits with a non-surgical treatment, according to researchers from Cleveland Clinic. In comparison. The findings also show that metabolic surgery may contribute health benefits that are independent of weight loss.
New data from the Centers for Disease Control and Prevention (CDC) show that adult obesity prevalence is increasing and adults with obesity are at heightened risk for severe outcomes from COVID-19. The ‘2019 Adult Obesity Prevalence Maps’ show that twelve states (Alabama, Arkansas, Indiana, Kansas, Kentucky, Louisiana, Michigan, Mississippi, Oklahoma, South Carolina, Tennessee, and West Virginia) now have an adult obesity prevalence at or above 35%, an increase from nine states in 2018 and six states in 2017.
In the COVID-19 special session at the Annual Meeting of the European Association for the Study of Diabetes (EASD), Professor Juliana Chan, (The Chinese University of Hong Kong and Prince of Wales Hospital, Shatin, Hong Kong, China) has presented a review of the evidence on the devastating impact COVID-19 is having on people with diabetes.
A study of approximately 200,000 blood samples from the UK Biobank has identified more than 2,000 undiagnosed cases of type 2 diabetes, according to a study presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD). As UK Biobank data is not reported back to participants, patients found to have undiagnosed diabetes waited on average more than two years for a clinical diagnosis and around a quarter remained undiagnosed five years later.
Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain, have shown how immune system cells, macrophages, have a key role in the regulation of obesity and the findings could be useful in the development of new treatments for people with obesity and overweight, and for some associated pathologies, including fatty liver disease and type 2 diabetes.
Metabolic surgery benefits people with morbid obesity and hypertension reducing their risk of major adverse cardiovascular event (MACE), according to a study, ‘Association between metabolic surgery and cardiovascular outcome in patients with hypertension: A nationwide matched cohort study’, published in PLoS Med.
Researchers at the Medical College of Georgia scientists are investigating an emerging obesity paradox that a new generation of HIV drugs appear to cause weight gain, which appears to limit, rather than increase patients' already significant risk of developing cardiovascular disease. Although these newer generation of HIV drugs have turned the once-lethal infection into a chronic condition, cardiovascular disease has emerged as the leading cause of death in these individuals.
The combined effects of the body's microbiota working together with COVID-19 in the lungs could explain the severity of the disease in people with obesity and diabetes, according to a paper, 'Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions', published in eLife,
ReShape Lifesciences has announced that the first 25 healthcare providers have partnered with ReShapeCare since the programme's launch in June of this year, allowing referrals of their patients to the reimbursable, virtual weight-management programme. Patients within the programme include individuals currently receiving treatment, those who may have lost continuity of care, patients pursuing bariatric surgery and those involved in a medically supervised weight-loss programme.
Ethicon has launched the of Echelon Endopath Staple Line Reinforcement (SLR), a novel buttressing device designed to further strengthen staple lines and reduce potential complications during bariatric, thoracic and general surgical procedures, in the US. This is the company’s first buttress solution designed for use with its own industry-leading Echelon Flex Powered Staplers with GST reloads, which have been associated with a lower rate of air leaks and bleeding complications1,2.
People who have been diagnosed with obstructive sleep apnoea could be at increased risk of adverse outcomes from COVID-19, according to a study from the University of Warwick. The conclusion is drawn from a systematic review of studies that reported outcomes for COVID-19 patients that were also diagnosed with obstructive sleep apnoea.
A study in mice has found that the estimated ten trillion bacteria living in your digestive system may shape your metabolism, as well as directly influencing biological processes from bowel movements to behaviour. Researchers in Daniel Mucida's Laboratory of Mucosal Immunology at Rockefeller University, have identified a particular type of gut neuron that controls blood sugar levels, influencing appetite.
A novel hydrogel platform technology to treat overweight, obesity and other chronic metabolic diseases, was the subject pf one oral presentation and two poster presentations showcasing notable efficacy data for Plenity (Gelesis 100) at the European and International Congress on Obesity (ECO-ICO 2020).
GI Windows Medical, a clinical-stage, privately-held medical device company, has raised US$16.4 million Series A-1 financing. The financing attracted Johnson & Johnson Innovation along with Sonder Capital, GT Healthcare, JC Investco and one additional strategic investor. In addition to the institutional financing, GI Windows also received investments from existing shareholders as well as new investors, the Kennedy Trust and Coleman Trust.
Young adults who have experienced weight stigma have more distress and maladaptive eating behaviours during the pandemic, regardless of their body size. Research from the UConn Rudd Center for Food Policy and Obesity and the University of Minnesota shows that young adults who experienced weight stigma before the pandemic have higher levels of depressive symptoms, stress, eating as a coping strategy, and are more likely to binge-eat during COVID-19, compared to those who have not experienced weight stigma.
ReShape Lifesciences has announced preclinical research demonstrating the its investigational Diabetes Bloc-Stim Neuromodulation (DBSN) proprietary device for the treatment of type 2 diabetes mellitus (T2DM) was well-tolerated and met the study endpoints. The study was conducted as a part of the National Institutes of Health (NIH) Small Business Innovation Research Phase I grant that was previously awarded in August 2019.
A pooled analysis of large-scale registry studies by UK researchers suggests that bariatric surgery is associated with reduced long-term all-cause mortality and incidence of obesity-related diseases (new-onset diabetes, high blood pressure, high cholesterol and heart disease etc) in patients with obesity for the whole operated population. The outcomes highlight that broader (increased) access to bariatric surgery for people with obesity may reduce the long-term sequelae of this disease and provide population-level benefits.
Young adults with underlying conditions such as morbid obesity, diabetes and hypertension are at the highest risk of being placed on a ventilator or dying from COVID-19, according to a study of 3,000 hospitalized patients aged 18 to 34. It confirmed first and foremost that black and Hispanic people have been the worst affected by the pandemic: they accounted for 57 percent of all young adults who were hospitalized and 49 percent of those who died or needed ventilation, representing about a third of all young people.
The number of people with pre-diabetes who go on to develop type 2 diabetes has been reducing over the past two decades, according to a study led by University of Manchester epidemiologists. However, the changes, according to lead author, Dr Rathi Ravindrarajah, are likely to be attributed to changes in the definition of pre-diabetes and recording practices, as well as preventative work by the NHS., such as the NHS Diabetes Prevention Programme.
Probiotics may help children and adolescents with obesity lose weight when taken alongside a calorie-controlled diet, according to a study presented at e-ECE (European Society of Endocrinology) 2020.
Researchers led by Imperial College Healthcare NHS Trust, London, UK, are looking to recruit participants to enrol in the Bariatric surgery vs. Medical care for obesity and polycystic ovarian syndrome related infertility (BAMBINI) randomised clinical trial. The study will examine the effects of bariatric surgery vs. lifestyle intervention in premenopausal women over the age of 18 with a diagnosis of polycystic ovarian syndrome (POCS) with a body mass index ≥35kg/m2 and less than eight menstrual periods a year.
People with obesity who intentionally (not because of illness) lost an average (median) 13% of their initial body weight reduced their relative risk of developing type 2 diabetes by 42%-44%, sleep apnoea by 22%-27%, high blood pressure by 18%-25%, and dyslipidaemia by 20-22%, according to a study of over 550,000 adults in primary care in the UK. The study authors believe it is the first of its kind to quantify the benefits of intentional weight loss on the risk of obesity-related conditions in real-world clinical practice.
People with obesity who gain weight have a tendency to perceive their own body size as smaller than it actually is compared to those who maintain a stable weight, according to research following more than 2,000 people with obesity from the Swedish Obese Subjects (SOS) study over ten years.
A detailed analysis of UK data from a global obesity study (the ACTION-IO study) has shown that, on average, people with obesity (PwO) in the UK were struggling with their weight for nine years before they sought help from a healthcare professional/HCP, much longer than the global average of six years. This delay puts PwO at additional risk of developing obesity-related conditions such as type 2 diabetes (T2D), obstructive sleep apnoea (OSA) and cancer. Additionally, more than half of the PwO had never discussed their weight with an HCP.
The latest findings from the annual Scandinavian Obesity Surgery Registry (SOReg) report could challenge existing recommendations and clinical practice for bariatric surgery and type 2 diabetes (T2DM) patients, according to the authors of a summary paper of the report, ‘Bariatric Surgery: There Is a Room for Improvement to Reduce Mortality in Patients with Type 2 Diabetes’, published in Obesity Surgery.
Males with obesity suffering from hypogonadism who have testosterone injections lost weight and saw improvement in a wide range of other metabolic parameters, according to research led by Dr Farid Saad, Consultant, Medical Affairs Andrology, Bayer AG, Berlin, Germany, and Gulf Medical University School of Medicine, Ajman, UAE, and colleagues. The study was presented at the European and International Congress on Obesity (ECOICO 2020).
Individuals whose overweight or obesity is diagnosed in hospital are 60% more likely to die compared to the general population, according to a nationwide Danish study that followed over 1.9 million people for up to 40 years, presented at The European and International Congress on Obesity. The risk of dying was highest within the first year of diagnosis but remained markedly higher for individuals with hospital-diagnosed overweight or obesity over the whole study period.
Data presented in a special COVID-19 session at the European and International Congress on Obesity (ECOICO 2020) suggests that there are overlaps between the immunological disturbances found in both COVID-19 disease and patients with obesity, which could explain the increased disease severity and mortality risk faced by patients with obesity and COVID-19. Since fat mass generally increases with ageing, this might also partly explain the increased death risk in older patients.
An online survey of nearly 3,000 UK adults suggests that people would prefer health professionals to use the words "weight", "unhealthy weight", and "overweight" when discussing weight status, and reveals parents' desire to avoid their children being referred to as "fat", "extra-large", or "plus size".
More than half of adults have found it difficult to manage their weight during the COVID-19 lockdown, according to the results of an online survey involving over 800 UK adults, presented at The European and International Congress on Obesity. Most of the respondents said their difficulties stemmed from increased snacking, not exercising as much as usual, increased anxiety or stress and not being able get hold of healthier food.
Findings from a positron emission tomography (PET) brain imaging study of the amygdala reveals that low levels of the enzyme aromatase, which catalyses oestrogen biosynthesis, are associated with a higher body mass index and lower self-control, as measured by a standard personality test.
Americans are less likely to blame people with obesity for their condition and are more likely to believe that obesity has a medical explanation now than three years ago, according to the results of two online surveys involving more than 6,000 UK and US adults. The outcomes were presented at the European and International Congress on Obesity (ECOICO 2020).
Scientists at Joslin Diabetes Center have delivered a proof of concept for a novel cell-based therapy for obesity that would by transplanting human brown-like (HUMBLE) fat cells, human white fat cells that have been genetically modified to become similar to heat-generating brown fat cells. The finding were reported in the paper, ‘CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice’, published in Science Translational Medicine.
People who consume frozen microbiome capsules derived from their own faeces when dieting may limit their weight regain, according to a study. ‘Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain’, published in Gastroenterology, conducted by a team of researchers led by Israeli researchers at Ben-Gurion University of the Negev (BGU).
Massachusetts Institute of Technology (MIT) researchers have devised a way to apply a temporary synthetic coating to the lining of the small intestine that could be adapted to deliver drugs, aid in digestion or prevent nutrients such as glucose from being absorbed, which could offer a new strategy to treat diabetes or obesity.
A review of COVID-19 studies has revealed an association between coronavirus and obesity, according to research led by the University of North Carolina at Chapel Hill, which raises concerns about the impact of obesity on the effectiveness of a future COVID-19 vaccine.
Patients hospitalised with COVID-19 who had a combination of high blood pressure, obesity and diabetes were over three times more likely to die from the disease, according to a study by researchers from Tulane University. The study, ‘Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans’, published in the journal Diabetes Care, is the first to look at the impact of metabolic syndrome on outcomes for COVID-19 patients.
A collaboration between Wyss Associate Faculty member, Dr Robert Wood and Robotics Engineer Hiroyuki Suzuki from the Sony Corporation has brought surgical robotics down to the microscale by creating a new, origami-inspired miniature remote centre of motion manipulator (mini-RCM). The robot is the size of a tennis ball, is light weight and successfully performed a difficult mock surgical task. A review of the technology, ‘Origami-inspired miniature manipulator for teleoperated microsurgery’ was published in Nature Machine Intelligence.
The resumption of elective bariatric and metabolic surgery is crucial and must be a priority similar to oncological surgery because it is not only a weight loss operation but also resolves or improves comorbidities and appears to be an immune restorative procedure of obese patients in the medium term, according to recommendations from IFSO’s Latin America Chapter. The paper, ‘COVID-19: IFSO LAC Recommendations for the Resumption of Elective Bariatric Surgery’, was published in Obesity Surgery.
A considerable group of bariatric surgery patients continue smoking after surgery despite advice to quit and temporary quitting before surgery, according to researchers from The Netherlands. The authors noted that this is the first study in bariatric surgery evaluating self-reported smoking behaviour combined with thoughts about the health consequences of smoking cessation and actual health outcomes in current, former and never smokers.
Intensive lifestyle intervention (ILI) aimed at weight loss lowered the incidence of obesity-related cancers in adults with overweight or obesity and type 2 diabetes, according to a randomised clinical trial that has examined long-term cancer outcomes in an ILI focused on weight loss by researchers from Johns Hopkins University in Baltimore, MD.
Researchers from the Helmholtz Zentrum München and the German Center for Diabetes Research (DZD) have reported that in men a genetic variant of the gene DUSP8 can increase the risk for type 2 diabetes by impairing the brain’s response to the hormone insulin. The findings were reported in the paper, ‘Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity’, in the Journal of Clinical Investigations.
Researchers from Washington University School of Medicine in St Louis have suggested that weight loss after bariatric surgery, rather than the surgery itself, drives metabolic improvements such as the remission of diabetes. Their findings were published in the paper, ‘Effect of diet versus gastric bypass on metabolic function in diabetes’, in The New England Journal of Medicine.
The prevalence of morbid obesity in a population is associated with negative outcomes from COVID-19, according to an analysis by researchers at The University of Alabama (UA) of morbid obesity data and reported COVID-19 deaths in the United States.
Stomach capacity in people with obesity changes to accommodate different eating situations, which has an effect on feelings of fullness and the urge to overeat, according to a study published in the American Journal of Physiology-Gastrointestinal and Liver Physiology.
There is sufficient evidence to demonstrate that One Anastomosis Gastric Bypass/Mini Gastric Bypass (OAGB-MGB) can be considered a safe and effective option as a revisional bariatric surgery procedures, according to an international team of researchers who carried out a systematic review of more than 1,000 patients.
A study of more than 26,000 patients has reported that bariatric surgery is associated with a lower risk for dying over the long-term, especially for heavier patients and those who have bariatric surgery at older ages. The outcomes were featured in the paper, ‘Association Between Bariatric Surgery and All-Cause Mortality: A Population-Based Matched Cohort Study in a Universal Health Care System’, published in the Annals of Internal Medicine.
Roux-en-Y gastric bypass (RYGB) is an effective strategy for midterm blood pressure (BP) control and hypertension remission with fewer medications required in patients with hypertension and obesity, according to the three-year results from the GAstric Bypass to Treat obEse Patients With steAdy hYpertension (GATEWAY) randomised clinical trial. The outcomes were published in the paper, ‘Three-Year Outcomes of Bariatric Surgery in Patients With Obesity and Hypertension Randomized Clinical Trial’, in the Annals of Internal Medicine.
There is a striking association between BMI and risk for death among patients with a diagnosis of COVID-19, reports a retrospective cohort study, ‘Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization’, published in the Annals of Internal Medicine. The association was independent of obesity-related comorbities and other potential confounders.
Vegetarian bariatric patients in East and South-East Asia are an under-recognized patient cohort at risk of micronutrient deficiencies, according to a survey of Asian surgeons by Asia-Pacific Metabolic and Bariatric Surgery Society (APMBSS). The study authors noted that current literature on micronutrient deficiency in this cohort is scarce, particularly in East and South-East Asian, and that there is a knowledge gap among regional surgeons in long-term nutritional assessment and management.
People who are overweight, even if only modestly, are at greater risk of COVID-19 hospitalization, according to researchers from University College London, UK. For the study, ‘Overweight, obesity, and risk of hospitalization for COVID-19: A community-based cohort study of adults in the United Kingdom’, published in the Proceedings of the National Academy of Sciences, researchers assessed UK Biobank data of more than 330,000 UK residents, taken between 2006 and 2010.
Changes in weight between young adulthood and midlife may have important consequences for a person's risk of early death, according to a Boston University School of Public Health (BUSPH) study.
Standard Bariatric’s Titan SGS stapling technology, which according to the company features the longest continuous stapler cutline (23cm), has been successful in an ongoing clinical trial at Buffalo General Medical Center, where the world’s first eight sleeve gastrectomy patients have been enrolled in the Investigational Device Exemption (IDE) study.
Researchers at the Lund University Diabetes Centre (LUDC) and the Centre for Analysis and Synthesis (CAS) have for the first time studied the effects of the strict low-calorie diet and the operation separately, and the results show that the diet alone accounted for the greatest positive effect. The findings are described in the paper, ‘Metabolic Effects of Gastric Bypass Surgery - is it all about Calories?’, published in the journal Diabetes
Obalon Therapeutics has executed a consulting agreement with Blue Ox Healthcare Partners, a private equity firm focused on commercial-ready companies bringing technology enabled innovation to healthcare, especially those involved in precision health, healthcare delivery and affordability.
The Echelon Powered Stapler with Gripping Surface Technology (GST) reloads (Ethicon) was associated with a lower rate of bleeding-related complications compared to the Signia Stapling System with Tri-Staple (Medtronic) among patients undergoing laparoscopic sleeve gastrectomy, according to the first real-world evidence study comparing these two powered surgical stapling systems.
Researchers from Michigan Medicine team has providing new insights into why patients with severe hyperglycaemia may trigger worse outcomes in people infected with COVID-19. The researchers have developed a blood sugar management tool that may potentially reduce risk of secondary infections, kidney issues and intensive care stays in people with diabetes, prediabetes or obesity who get COVID-19. The reported their findings in the paper, ‘Managing Hyperglycemia in the COVID-19 Inflammatory Storm’, published in Diabetes.
A compound given as a dietary supplement to overweight but otherwise healthy people in a clinical trial caused many of the patients to lose weight, according to research by Oregon State University and Oregon Health & Science University. The research, ‘A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations’, was published in The Journal of Nutrition.
Obesity increases the release of tumour-promoting molecules from fat tissue and is associated with an increased risk of breast cancer, according to a study, ‘Obese adipose tissue extracellular vesicles raise breast cancer cell malignancy’, published in Endocrine-Related Cancer.
A study from Harvard Medical School (UMS) and Brigham and Women's Hospital reveals the latest piece of the puzzle of how bariatric surgery can lead to healthier blood sugar levels. The paper, ‘Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects’, published in Nature Chemical Biology, reports that that a specific bile acid rises in the guts of mice and humans after bariatric surgery and sets off a chain of biochemical events that lowers high blood sugar.
Nestlé Health Science and Epitomee Medical have entered into a strategic partnership for the development and commercialisation of an innovative polymer-based ingestible product aimed at promoting weight loss and improving health. The strategic partnership will cover the development and the commercialisation of the product which has already demonstrated efficacy and safety in various pre-clinical and clinical studies with significant weight loss reduction and other beneficial health impacts.
Researchers at Beth Israel Deaconess Medical Center (BIDMC) who followed up 107 patients who were denied the procedure in 2007, have reported that most patients who were initially turned away eventually obtained bariatric surgery, experienced improved overall health and were still living at 12- year follow up. However, 40 percent of those denied surgery in 2007 who never underwent the procedure were deceased by 2019.
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to Shaw Somers about how the bariatric community can safely resume surgery...
1. Although the pandemic has sadly resulted in the loss of many people, the risk of dying from the virus is low for most people (some 80% are asymptomatic). What can be done to reassure patients thinking about bariatric surgery but who are also worried about possibly acquiring the virus in hospital or shortly after their procedure?
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to Ricardo Cohen about how the bariatric community can safely resume surgery...
1. Our survey showed that the vast majority of bariatric specialists do not support prioritising surgery for low-BMI groups and non-diabetic patients. Do you believe there any group of patients who should be prioritised?
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to Monika Proczko-Stepaniak about how the bariatric community can safely resume surgery...
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to Ahmed Bashir about how the bariatric community can safely resume surgery...
1. When you consider all the recommendations and best practices around the globe, what do you think is the first priority for your respective country to focus in terms of managing obese patients during & after COVID-19?
Body mass index (BMI) is associated with the development of severe coronavirus disease 2019 (COVID-19) and admission to intensive care units (ICU) in African Americans, according to researchers from the Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine at Tulane University Health Science Center in New Orleans, LA. The outcomes were published in the paper, ‘BMI is Associated with Coronavirus Disease 2019 Intensive Care Unit Admission in African Americans’, in Obesity, the flagship journal of The Obesity Society.
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to Michel Gagner about how the bariatric community can safely resume surgery...
1. There has been much debate surrounding the use of radiofrequency energy/ electrothermal bipolar devices versus ultrasonic coagulating devices, with regards to the possible risk of infection through aerosolization. What are your thoughts on device use and aerosolization?
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to current IFSO-EC President, Gerhard Prager about how the bariatric community can safely resume surgery...
1. Two of many key recommendations from a recent IFSO publication that you co-authored, 'How are We Going to Restart Elective Bariatric and Metabolic Surgery after the Peak of Covid-19Pandemic?’ concerned pre- and post-operative care consultations.
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to past IFSO President, Kelvin Higa about how the bariatric community can safely resume surgery...
1. What have been the most important changes you have developed at your centre to the ‘bariatric patient pathway’ to ensure the safety of both the patient and bariatric and metabolic specialists?
Obesity management should focus on outcomes that patients consider to be important - not weight loss alone and include a holistic approach that addresses the root causes of obesity, according to a new clinical practice guideline published in Canadian Medical Association Journal.
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to current IFSO President, Lilian Kow about how the bariatric community can safely resume surgery...
1. As the current president of IFSO, what steps has the Federation taken to help promote the safe return to surgery for patients and bariatric specialists?
The outcomes of an online survey conducted by Bariatric News has revealed that there is little consensus among bariatric and metabolic specialists around prioritising specific groups (non-diabetics, BMI, age) when bariatric surgery is resumed during the current COVID-19 pandemic. However, there was a high degree of consensus concerning testing, personnel protective equipment, who should perform surgery and utilising post-operative tele-conferencing.
Men who were overweight or had obesity as adolescents have a substantial risk increase for developing venous thromboembolism (VTE) later in life compared with those who were not overweight or had obesity when they were adolescents, according to research headed by Sahlgrenska Academy at the University of Gothenburg in Sweden.
Allurion Technologies has announced the company’s entry into Asia with the launch of the Elipse Program in Hong Kong, Malaysia, and Singapore. Building upon its success in Europe, Middle East, and Latin America, the company’s entry into Asia could impact the lives of over one billion people who are overweight or have obesity in a region that historically has had limited access to non-invasive weight loss treatments.
Internet-connected surveillance as part of a bariatric surgery enhanced recovery after surgery (ERAS) programme was safe and effective in detecting 100% of early complications and most patients were satisfied with their care, according to researchers from France. The findings were reported in the paper, ‘Connected Surveillance for Detection of Complications After Early Discharge from Bariatric Surgery’, was published in Obesity Surgery.
The British Obesity & Metabolic Surgery Society and Obesity UK have responded to the UK government’s recently announced obesity strategy to get the nation fit and healthy, protect themselves against COVID-19 and protect the NHS.
Patients with obesity are at higher risk of developing heart failure and yet, many obese patients face obstacles to getting heart transplants, as recovery is considered to be more challenging and risky in individuals with high body mass. Some physicians have attempted to pair bariatric surgery, which has shown to effectively reduce body mass in some patients, with LVAD surgery - considered a bridge to heart transplantation. However, the studies in general were too small to assess whether the approach was generalizable.
Publicly funded Roux-en-Y gastric bypass (RYGB) appeared to be higher in the first three years but similar thereafter to the costs of non-surgical interventions, according to the paper, ‘Association of Roux-en-Y Gastric Bypass With Postoperative Health Care Use and Expenditures in Canada’, published in JAMA Surgery. The study found that hospital and emergency department (ED) readmissions after surgical bariatric interventions were associated with increased health care expenditures.
The UK government has revealed a raft of measures as part of the government’s new obesity strategy to get the nation fit and healthy, protect themselves against COVID-19 and protect the NHS. Living with excess weight puts people at greater risk of serious illness or death from COVID-19, with risk growing substantially as BMI increases. Nearly 8% of critically ill patients with COVID-19 in intensive care units have been morbidly obese, compared with 2.9% of the general population.
Bariatric surgery can improve female sexual function decreasing the risk of sexual dysfunction presence and the advantages are associated with the total BMI loss, according to researchers from Medical University of Warsaw and the Military Institute of Medicine, Warsaw, Poland. The outcomes were featured in the paper, ‘The effect of bariatric surgery on female sexual function: a cross-sectional study’, published in Scientific Reports.
Lexington Medical, a US-based medical device company delivering minimally-invasive surgical stapling solutions, and BOWA Medical, a leading innovator of energy based surgery products for medical applications, have entered into a commercial agreement.
One-year outcomes from a study evaluating the RefluxStop device (Implantica) has found the device is safe and effective when treating gastroesophageal reflux disease (GERD), with no complications related to the device and complications caused by the compression of the food passageway (ie. dysphagia, odynophagia and gas bloating) are not an issue with the RefluxStop procedure. The outcomes were reported in the paper, ‘Non-active implantable device treating acid reflux with a new dynamic treatment approach: 1-year results’, published in BMC Surgery.
The two-year outcomes from the Tehran obesity treatment study (TOTS), which is comparing the effectiveness and safety of sleeve gastrectomy (SG) and gastric bypass (GB), has reported that both surgical procedures are effective in the control of obesity and remission of its comorbidities. However, since SG was associated with a lower rate of complications, it seems that SG should be considered as a suitable procedure for obese patients, especially those with a healthier metabolic profile, the authors report.
A review article in Therapeutic Advances in Gastroenterology describes the refinement of EsophyX technology (EndoGastric Solutions) and the evolution of transoral incisionless fundoplication (TIF) as a safe and effective treatment for patients with gastroesophageal reflux disease (GERD).
Apollo Endosurgery has submitted a 510k submission of the X-Tack Endoscopic HeliX Tacking System to the FDA seeking clearance for the new, through-the-scope, suture-based device designed specifically for closing defects in the lower gastrointestinal tract with additional applications in the upper gastrointestinal tract.
Olympus has launched the EVIS X1 endoscopy system to improve outcomes from disorders of the stomach, colon and oesophagus, as well as from bronchial diseases. EVIS X1 supports accurate screening and confident diagnosis through introducing new and easy-to-use technologies to support how gastrointestinal disorders, such as colorectal cancer (CRC), or bronchial diseases are detected, characterised and treated.
The risk of greater COVID-19 severity and death is higher in people with BMI>30 according to a study published in the European Journal of Endocrinology. The study findings showed that BMI>30 was associated with a significantly higher risk of respiratory failure, admission to intensive care and death in COVID-19 patients, regardless of age, gender and other associated diseases.
A new Northwestern Medicine remote weight-loss programme, called Opt-IN, provides maximum weight loss for the lowest cost and with much less hassle than the gold-standard National Diabetes Prevention Program (DPP), according to the outcomes from a clinical trial. The DPP is claimed to be the most successful behavioural non-drug treatment currently available. Outcomes from the Opt-IN programme show that participants in a clinical trial lose 11 to 13lbs, which is equivalent to the DPP's success rate.
Users of public insurance are paying more for bariatric surgery compared to private insurance patients, according to researchers the University of Georgia.
Prior bariatric surgery (prior-BS) in type 2 diabetes mellitus (T2DM) patients undergoing noncardiac surgery is associated with a lower risk of major adverse cardiovascular and cerebrovascular events (MACCEs), according to researchers from The First Affiliated Hospital, Sun Yat-Sen University, South China University of Technology, Guangzhou and the Second Military Medical University, Shanghai, China.
IFSO Endoscopy Committee has published a Position Statement on the best practise of bariatric endoscopy in response to the CVOID-19 pandemic. The statement offers guidance on navigating bariatric endoscopic procedures in patients with obesity during the COVID-19 pandemic, in the hope of mitigating the risk of SARS-CoV-2 transmission to vulnerable patients and healthcare workers. The statement acknowledges that the recommendations may evolve as the pandemic progresses.
African American (AA) patients undergoing bariatric surgery are younger and heavier than non-AA patients, present with different comorbidity profiles and exhibit worse outcomes following Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) than non-AA patients, including increased mortality rates in AA-SG patients.
Breast cancer patients who are overweight or have obesity might benefit less from treatment with docetaxel, a common chemotherapy drug, than lean patients, according to an international team of researchers who carried out a retrospective analysis of data from a large clinical trial.
A team of Australian paediatric specialists, including an expert from the University of Adelaide, has produced new guidelines regarding assessment and management of type 2 diabetes (T2D) in Australian and New Zealand children and adolescents. With the incidence of T2D on the rise among children and adolescents, especially in Indigenous communities, early assessment and management is critical.
A new guideline from the Canadian Task Force on Preventive Health Care, based on a rigorous systematic review of the latest evidence, found no benefit of routine screening for oesophageal adenocarcinoma (EAC) and precursor conditions (Barrett oesophagus and dysplasia) in patients with chronic gastroesophageal reflux disease (GERD).
People among black and minority ethnic communities (BME) who have obesity are around two times higher the risk of contracting COVID-19 compared to white Europeans, according to a study conducted by a team of Leicester researchers.
Researchers at Yale have identified a molecule that plays a key role in the body's inflammatory response to overeating, which can lead to obesity, diabetes and other metabolic diseases. The finding suggests that the molecule could be a promising therapeutic target to control this inflammation and keep metabolic diseases in check. The study, ‘OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance’, was publishing in the Proceedings of the National Academy of Sciences.
Researchers from Osaka University, Japan, have developed a novel vaccine that removes aged immune cells and then demonstrated an improvement of diabetes-associated metabolic derangements by vaccinating mice with obesity. The study, 'The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice', was published in Nature Communications.
Researchers from Obesity Center Máxima, Máxima Medical Center, Department of Surgery, Eindhoven/Veldhoven, in the Netherlands, have initiated the ‘Banded Roux-en-Y gastric bypass in patients with superobesity (BRandY-study)’ to assess the added value of the banded Roux-en-Y gastric bypass in patients with super-obesity (BMI>50) on long-term weight loss outcomes.
One of the first studies to define and examine the perceptions ‘bariatric families’ towards obesity has reported that there are significant differences between the perceptions of those parents and children – in a ‘bariatric family’ - toward themselves, their health and the preferred mode of obesity treatment, compared to non-bariatric families, according to researchers from Dana Dwek Children’s Hospital and Tel Aviv University, Tel Aviv, Israel.
Researchers from Europe have initiated the first randomised controlled trial that will compare sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) in adolescents with severe obesity. The TEEN-BEST trial is designed to determine whether SG is non-inferior to RYGB in terms of total body weight (TBW) loss.
An international team of bariatric and metabolic surgery (B&M) experts has published a series of protocols designed to assist B&M surgeons and Allied Healthcare Professionals when restarting elective B&M surgery following the outbreak of COVID-19, based on experts’ opinions, reviews of small series and publications from previous different viral epidemic outbreaks.
Type 2 diabetes can be reversed in more than 60% of participants through dietary change, physical activity and behaviour change, and without medication or bariatric surgery, according to a team of researchers from Qatar. These were the conclusions from the DIADEM-I clinical trial, thought to be the first intensive lifestyle intervention trial in the Middle East and North Africa region and is the country’s first clinical trial in primary care.
Obesity is associated with a higher risk of dementia up to 15 years later, according to a study by researchers from University College London, London, UK, suggesting that weight management could play a significant role in reducing the risk of dementia. These findings have significant implications for dementia prevention and overall public health.
The FDA has approved the expansion of a US- pilot study of the USGI Medical’s non-invasive, endoscopic procedure, known as POSE2.0. The study is designed to evaluate weight loss for adults suffering from obesity with a BMI35-40 and obesity-related comorbidities, such as diabetes or hypertension. The FDA approval, based on the promising results obtained so far from the first stage of the study, means the pilot study will be expanded to four US institutions and 35 US subjects.
Gelesis, who recently received European approval for its PLENITY weight loss treatment, has entered into a partnership with China Medical System Holdings Limited (CMS) for the commercialisation of Plenity in China. The partnership will build on Gelesis’ commitment to providing patient-initiated care for adults with overweight and obesity that augments traditional healthcare provider services with digital access to care.
Bariatric surgery may decrease overall cancer risk in women, but not men, within the first five years after surgery, and according to the study’s researchers the decrease may be explained by a decreased risk of breast and endometrial cancer and non-Hodgkin lymphoma in women.
ReShape Lifesciences has entered into a partnership with inHealth Lifestyle Therapeutics (formerly inHealth Medical Services), a Lifestyle Therapeutics company, to launch the ReShapeCare virtual health coaching programme in June 2020. The service is tailored for patients having treatment for their obesity, those who may have lost continuity of care and patients pursuing weight loss surgery and medically supervised weight loss programmes.
The American Society for Metabolic and Bariatric Surgery (ASMBS) has declared metabolic and bariatric surgery "medically necessary and the best treatment for those with the life-threatening and life-limiting disease of severe obesity" and called for the safe and rapid resumption of procedures, which have been largely postponed along with other surgeries deemed elective amid the COVID-19 pandemic.
Researchers from Eindhoven University of Technology, The Netherlands, are working on mathematical models that show the human metabolism for each person. The DigiTwin research project, led by Natal van Riel, aims to build a digital copy of individual patients to predict the success and to determine the necessary aftercare of a treatment such as gastric bypass surgery in patients with obesity.
The Intellectual Property Office has granted Benmor Medical patent no. EP3315107 on the Aurum+ Bariatric Bed, entitled: ‘Barrier for a Bed’ in the UK and Europe. This decision adds to the company’s patent portfolio for the features on its innovative Deprimo Floor Level Bed.
Novo Nordisk has announced the headline results from two clinical trials with a novel once-weekly subcutaneous amylin analogue (AM833), a phase 2 monotherapy trial and a phase 1 combination trial of AM833 and once-weekly subcutaneous semaglutide 2.4mg.
From 13-14 June 2020, the First International Conference “Controversies in bariatric surgery” (CIBS 2020) was held in St Petersburg, Russia, and due to the COVID-19 pandemic was implemented in an innovative online format, organised by the Society of Bariatric Surgeons of Russia, with the support of IFSO, together with the company Uniclinic.
Gelesis, a biotechnology company developing a novel hydrogel platform technology to treat obesity and other chronic diseases related to the gastrointestinal (GI) tract, has received approval to market Plenity, a novel weight loss treatment, in Europe. Gelesis received a Conformité Européenne (CE) mark for Plenity as a class III medical device indicated for weight loss in overweight and obese adults with a BMI25-40, when used in conjunction with diet and exercise.
Researchers from Iran performing laparoscopic mini-gastric bypass/one anastomosis gastric bypass (MGB/OAGB) have reported that 180cm intestinal bypassed length works for patients with a BMI40–45 and 45–50 with significant decreases in weight and BMI, and improvements in glycolipid profiles.
One anastomosis gastric bypass (OAGB-MGB) has a less steep learning curve compared to Roux-en Y gastric bypass (RYGB), according to researchers Fang Hospital, Taipei Medical University, Taipei City, Taiwan. The study also reported that the proficiency acquired can be transferred to subsequent practice for RYGB in terms of acceptable operation time and length of stay without an increase in complications.
A study investigating the prevalence and analysing the role of fascia closure in the development of trocar hernias has reported that trocar site hernias are an underestimated complication of minimally invasive, multi-portal bariatric surgery, and the prevalence of asymptomatic hernias is probably higher than initially expected. The study also found that fascia closure did not protect against trocar hernias.
If a child is infected with the new coronavirus, having obesity appears to greatly raise the odds for developing a severe form of COVID-19, according to a report was based on 50 cases of paediatric COVID-19 severe enough to require admission to a New York City hospital.
Routine post-sleeve gastrectomy gastrografin (RSG) to detect post- laparoscopic sleeve gastrectomy (LSG) complications, especially leaks, is needless and unnecessarily increases the overall costs as it makes no difference in detecting leaks, according to researchers from Saudi Arabia.
A letter published in the New England Journal of Medicine, and signed by an international group of 17 leading diabetes experts from the multidisciplinary Diabetes Surgery Summit (DSS), has announced the creation of the CoviDiab project. The CoviDiab project is a collaborative international research initiative that has established a Global Registry to collect new cases of diabetes in patients with COVID-19.
Bariatric News is carrying out a survey of Bariatric and Metabolic Surgeons and Allied Healthcare Professionals to collect and report their views on safely returning to bariatric surgery post COVID-19.
The survey is anonymous and only takes 2 minutes (13 questions) to complete. The outcomes will be published on www.bariatricnews.net in the coming weeks.
Please click here to access the survey.
Researchers at the Francis Crick Institute have found two genes that regulate the differentiation of stem cells in the small intestine, offering valuable insight into how the body develops and maintains a healthy gut.
Cells in the lining of the small intestine are replaced around every five days, the quickest rate for any organ in the body. This fast replacement helps the lining cope with the damage it suffers as a result of breaking down food and absorbing nutrients.
Researchers from the Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, investigating the effect of a Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), liraglutide, on pancreatic volume, oedema, cellularity and DNA synthesis in humans, have reported that increased markers are not a sign of pancreatitis, but that GLP‐1RAs is creating a new normal state, a so-called new steady state, in the patients.
Roux-en-Y gastric bypass surgery (RYGB) is more effective than best medical treatment (BMT) for achieving remission of albuminuria and stage G1 to G3 and A2 to A3 CKD in patients with type 2 diabetes and obesity at 24 months, according to the results of a randomised clinical trial by researchers from Brazil.
Body mass index is likely to be an inconsistent measure of obesity in Māori and Pacific patients, according to a study by University of Otago researchers. Specifically, researchers from HeartOtago - a group of cardiovascular researchers and clinicians located at the University and Dunedin Hospital - looked at epicardial adipose tissue (EAT), a special form of fat surrounding the heart which has been linked to increased risk of heart attacks and disturbances in heart rhythm.
Sleeve gastrectomy (SG) might be the best option for weight loss in patients in whom fractures could be a concern, compared with Roux-en-Y Gastric Bypass (RYGB) which maybe be associated with an increased fracture risk, according to researchers from Rush University Medical Center, Chicago, IL.
Participants had a wide range of metabolic responses after eating in apparently healthy adults and that inflammation triggered by the food they consumed varied up to ten-fold, according to researchers led by King's College London after they published the first published results from PREDICT, the largest ongoing nutritional study of its kind. The results were featured in the paper, ‘Human postprandial responses to food and potential for precision nutrition’, published in Nature Medicine and presented at the American Society of Nutrition 2020.
Researchers have identified a small mitochondrial uncoupler, named BAM15, that decreases the body fat mass of mice without affecting food intake and muscle mass or increasing body temperature. Additionally, the molecule decreases insulin resistance and has beneficial effects on oxidative stress and inflammation.
The COVID-19 pandemic is having a significant impact on people with obesity as they struggle to manage their weight and mental health during shelter-in-place orders, according to research led by The University of Texas Health Science Center at Houston (UTHealth) and UT Southwestern.
In the largest study of the genetics of childhood obesity, researchers have looked at why some children gain weight very easily and have identified three genes that might be playing an important role in controlling a person's weight.
Scientists at Cincinnati Children's and the University of Cincinnati College of Medicine have outlined the details of new cellular process that shows how adipocytes’ (fat calls) immune response worsens obesity. The team reports that type I interferons, a class of substances produced by immune cells also are produced by fat cells called adipocytes. These interferons drive a constant low-level, chronic immune response that amplifies "vigour” to a cycle of inflammation within white adipose tissue (WAT).
United Imaging has received FDA clearance of the uMR OMEGA magnetic resonance imaging (MRI) scanner, the world’s first ultra-wide 75-cm bore. With the widest bore in the market at any field strength, uMR OMEGA provides a unique, patient-centric experience designed to accommodate a wide range of patients. With a 75-cm bore and 680lbs table capacity, uMR OMEGA addresses evolving demographics in the US community, not only improving patient comfort for all but creating, for the first time, an MRI for bariatric patients.
Investigators at Flinders University have found that the nutrient sensing capacity of Enterochromaffin (EC) cells, which line the gastrointestinal tract and are the source of almost all serotonin in the body, change in mice under the influence of high-fat diet-induced obesity and metabolic disease.
Surgeons at UT Southwestern Medical Center have pioneered a new technique that prevents nipple discoloration and preserves shape in men who undergo breast reduction surgery following significant weight loss. The procedure, described in the paper, ‘An Alternative Treatment of Pseudogynecomastia in Male Patients After Massive Weight Loss’, was published in the Aesthetic Surgery Journal Open Forum.
Less family discouragement and better family communication is associated with a higher likelihood to eat evening family meals and family breakfasts together, and not in front of a television, according to the paper, ‘Family Meal Practices and Weight Talk Between Adult Weight Management and Weight Loss Surgery Patients and Their Children’, published in the Journal of Nutrition Education and Behavior.
Novo Nordisk has announced headline results from Semaglutide Treatment Effect in People with obesity (STEP) 1, a phase 3a trial in the STEP programme, which revealed the study met both primary endpoints. STEP 1 is a 68-week randomised, double-blind, multicentre, placebo-controlled weight management trial.
Fractyl Laboratories has received approval from the FDA of an Investigational Device Exemption (IDE) to begin a pivotal study of Revita DMR in type 2 diabetes (T2D) patients treated with insulin. This landmark pivotal study, called Revita T2Di, is a prospective, randomised, double-blind, sham-controlled study enrolling 300 patients at up to 35 sites around the world, with approximately 25 sites in the US.
Laparoscopic banded sleeve gastrectomy (LBSG) appears to be significantly more effective than laparoscopic sleeve gastrectomy (LSG) in terms of weight loss in the midterm follow-up, according to researchers from Italy. The randomised study, ‘Banded Sleeve Gastrectomy Improves Weight Loss Compared to Nonbanded Sleeve: Midterm Results from a Prospective Randomized Study’, published in the Journal of Obesity, sought to compare LBSG and LSG over a four-year follow-up.
Ethicon has announced its continued support of guidelines from the Society for American Gastrointestinal and Endoscopic Surgeons (SAGES), which recommends the use of personal protective equipment (PPE) and smoke evacuation in the operating room during laparoscopic and open surgery.
Xeris Pharmaceuticals has announced positive findings from the outpatient stage of a Phase 2 proof-of-concept study of its developmental ready-to-use (RTU) glucagon in patients who experience postprandial hypoglycaemic episodes following bariatric surgery.
Researchers from the University of British Columbia, Canada, believe they have identified a gene that may prevent weight gain, after using a genetic database of more than 47,000 people in Estonia. The gene is linked to thinness and may play a role in resisting weight gain in these metabolically healthy thin people. Deleting the gene resulted in thinner flies and mice, and that the expression of it in the brain may be involved in regulating energy expenditure.
Boston University School of Medicine researchers have discovered that anti-obesity medications such as phentermine and topiramate, used individually or in combination, can significantly reduce weight regain in patients after Roux-en-Y gastric bypass surgery. The retrospective study paper, 'The Mitigating Effect of Phentermine and Topiramate on Weight Regain after Roux-en-Y Gastric Bypass Surgery', was published in Obesity.
The British Obesity and Metabolic Surgery Society (BOMSS) has written a letter to British Prime Minister, Boris Johnson, welcoming his plans to launch an anti-obesity strategy and urging him to take urgent action to help the NHS to rapidly introduce effective treatment for people with severe obesity.
Post-bariatric surgical guidelines focus on a range of follow-up protocols that record and follow a patient’s glycaemic control, blood lipid profile, obstructive sleep apnoea, gastroesophageal reflux disease, body weight, etc.
Baxter International will provide financing for a grant-funded fellowship coordinated in conjunction with the European Society for Clinical Nutrition and Metabolism (ESPEN), which will significantly contribute to the ESPEN Fellowship Grants initiative and increase the number of early-career researchers awarded, allowing to fund and develop more original research in topics related to nutrition and metabolism.
Preoperative weight loss, even at a moderate degree (ie >0% to <5%), is associated with lower risk of 30-day mortality following bariatric surgery, according to a study involving nearly half a million patients by researchers from University of Iowa College of Public Health, the University of Iowa, Iowa City, and Renmin Hospital of Wuhan University, Wuhan, China.
Allurion is supporting customers around the world during COVID-19 with an expanded digital offering, in response to recent data that indicates that individuals with obesity are at higher risk of poorer outcomes from COVID-19 and that quarantine measures may lead to weight gain. The company has expanded access to telenutrition for both existing and new patients and providers, and enhanced its proprietary program to include at-home fitness, mental health and nutritional content.
Researchers from the Hubrecht Institute and Utrecht University have generated an in-depth description of the human hormone-producing cells of the gut in a large collaborative effort with other research teams. In the study, ‘High Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells’, published in the journal Cell, the researchers developed an extensive toolbox to study human hormone-producing cells in tiny versions of the gut grown in the lab called organoids.
Analysis of data from 147 countries has uncovered new insights into the positive relationship between national income and obesity rates, according to researchers from State University of New York at Buffalo. The study, ‘The association between national income and adult obesity prevalence: Empirical insights into temporal patterns and moderators of the association using 40 years of data across 147 countries’, was published in PLoS ONE.
Researchers from Trinity College Dublin are calling on the government in Ireland to change recommendations for vitamin D supplements after publishing data that highlights the association between vitamin D levels and mortality from COVID-19.
An international team of experts has issued a guidance paper that identifies patients with the greatest need for bariatric and metabolic surgery, as experts warn delaying treatment could put them at a greater risk of complications from their disease, as well as from COVID-19.
Scientists from the University of Gothenburg, Sweden, have found a new method of reducing human body weight and fat mass using weighted vests. The outcomes from the study indicate that there is something comparable to built-in bathroom scales that contributes to keeping body weight and, by the same token, fat mass constant.
Men who had obesity in their late teens are more at risk of venous thromboembolism (VTE) in the leg or lung in adult life, according to a study from the University of Gothenburg study. The risk rises successively and is highest in those who had severe obesity in adolescence. The outcomes were reported in the paper, 'Obesity in adolescent men increases the risk of venous thromboembolism in adult life', published in the Journal of Internal Medicine.
Despite overall increases in insurance coverage for low-income individuals in Medicaid expansion states, some gaps remain for individuals who have obesity, according to a recent study by a team of researchers at the University of Georgia.
UK research has found that being male or having obesity reduces chance of survival from COVID-19.
In a recent study, ‘Banding the Pouch with a Non-adjustable Ring as Revisional Procedure in Patients with Insufficient Results After Roux-en-Y Gastric Bypass: Short-term Outcomes of a Multicenter Cohort Study’, published in Obesity Surgery, researchers from The Netherlands reported the outcomes from the first multi-centre revisional banded bypass procedure in a relatively high number of patients.
The FDA has provided an update on the potential risks of over-inflation (spontaneous hyperinflation - the spontaneous filling of intragastric balloons with additional air or liquid while inside a patient’s stomach, typically resulting in the need for early device removal), acute pancreatitis and deaths in patients with Orbera and ReShape liquid-filled intragastric balloons used for weight loss in adult patients with obesity.
On Thursday, 30th April 2020, from 18:00 – 20:00 (Central European Time), BARIAlink will host the 35th BARIAlink Academy Virtual Classroom, with the aim of improving the knowledge and skills of bariatric and metabolic specialists to deal with complex cases. This latest online virtual classroom will consist of a series of presentations, discussions and polls, and will feature a special topic on ‘Visceral obesity: impact on COVID-19 pneumonia’, by Prof Dr Jan Mulier (AZ Sint Jan Brugge, Belgium).
In April 2019, Drs Michel Gagner (Hopital du Sacré Coeur, Montréal, the Westmount Square Surgical Center, Westmount, QC, Canada and the Herbert Wertheim School of Medicine, Florida International University, Miami, USA) and Paul Kemmeter (Mercy Health Saint Mary’s, Grand Rapids, MI, USA) published a systematic review comparing staple-line leak rates in five reinforcement options following laparoscopic sleeve gastrectomy (LSG) in the journal Surgical Endoscopy1.
An international review has reported that elderly people with diabetes who contract COVID-19 are at a much higher risk of dying from the disease and the virus may actually trigger the onset of diabetes in normally healthy people. Authored by an international panel of experts in the field of diabetes, they came together to provide guidance and practical recommendations for the management of diabetes for clinicians in both developed and developing countries.
Researchers at the Max Planck Institute for Metabolism Research in Cologne, Germany, have discovered that a group of nerve cells in the brains of mice promotes the consumption of high-fat food. If these so-called nociceptin neurons in the hypothalamus are activated, the animals start to eat more. The findings, ‘PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding’, were published in the journal Neuron.
Adolescent obesity is a serious and growing public health problem that threatens both current and future health outcomes, according to an editorial by Drs Leonard H Epstein (SUNY Distinguished Professor and Division Chief of Behavioral Medicine in the Department of Pediatrics in the Jacobs School of Medicine and Biomedical Sciences at University at Buffalo (UB)) and Teresa Quattrin (a UB Distinguished Professor and senior associate dean for research integration in the Jacobs School).
A study led by Yale Cancer Center (YCC) researchers has demonstrated in mice that hormones released from the pancreas itself can advance pancreatic cancer and that weight loss can stop this process in its early stages. Pancreatic cancer is expected to become the second-deadliest cancer in the US by 2030, driven in part by rising obesity rates. The research, ‘Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma’, was published in the journal Cell.
A meta-analysis designed to determine the hierarchies of different bariatric surgeries in patients with obesity and type 2 diabetes mellitus (T2DM), has reported that one anastomosis (mini) gastric bypass (OAGB/MGB) is more likely to achieve diabetes remission compared with other bariatric surgeries. However, biliopancreatic diversion without duodenal switch (BPD) appears to be the most effective surgery for achieving long‐term diabetes remission.
The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) continues to provide recommendations and information regarding surgical response to the COVID19 crisis, which are intended to provide surgeons with additional information to help manage surgical patients during the COVID-19 pandemic. They are not formal guidelines and, due to time constraints, SAGES has not reviewed them by utilising its standard rigorous guidelines process.
Obesity increases the risk of developing type 2 diabetes mellitus (T2DM) by at least six times, regardless of genetic predisposition to the disease, according to research, ‘Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study’, published in Diabetologia (the journal of the European Association for the Study of Diabetes, EASD).
Individuals with diabetes are at increased risk for bacterial, parasitic and viral infections, according to a study, ‘Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications’, published Endocrine Reviews, and demonstrates how intersections of the coronavirus infection (COVID-19) and type 2 diabetes may require new approaches in treatment for hospitalised patients.
The International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) has issued recommendations to its global healthcare providers aimed at keeping all metabolic and bariatric surgery patients and practice staff in a safe as environment as possible.
Younger people with obesity are at higher risk of developing severe COVID-19 symptoms, according to two studies published in the journals Clinical Infectious Diseases and medRxiv, which highlight that inflammation throughout the body associated with obesity could be a powerful factor in the severity of COVID-19 and could be even more significant than heart or lung disease.
A UCLA study conducted with mice has found that a gene called reprimo, which is expressed by certain neurons in the brain, may play a role in menopause-related weight gain, a phenomenon not linked to increased eating. Their findings were featured in the paper, ‘Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure’, published in Nature Metabolism.
Apollo Endosurgery has announced that the FDA has completed the review of the final Post-Approval Study (PAS) Report for the ORBERA Intragastric Balloon System and accepted that all post-approval study requirements have been fulfilled. The ORBERA Post Approval Study was a requirement following the US FDA's approval of ORBERA in August of 2015. The study was a multi-centre, open label, prospective study with a primary safety endpoint and its secondary endpoint being effectiveness. All study endpoints were successfully met.
Researchers from in the Department of Microbiology and Immunology and UofL Health, James Graham Brown Cancer Center at the University of Louisville, have published an article which proposes a unique theory that a protein secreted by fat cells drives the development of breast cancer.
The behaviour of previous coronaviruses together with physiological characteristics of diabetes may help explain why people with diabetes have a higher risk of developing COVID-19, a respiratory disease caused by the novel coronavirus SARS-CoV-2, according to a paper, ‘COVID-19 Pandemic, Corona Viruses, and Diabetes Mellitus’, published in the American Journal of Physiology-Endocrinology and Metabolism.
Enara Health, a developer of a technology-powered personalised weight loss programme, is expanding telehealth availability of its programme to all residents in California, Texas and Illinois. This rollout represents an earlier-than-planned first stage of a US rollout of the Enara Health platform, a clinical weight loss programme that takes a multi-faceted approach to obesity treatment.
Researchers from Brigham and Women's Hospital who paired an online weight loss programme with a phone- and email-based population health management programme (two-pronged strategy), have found that patients in the combined programme had greater weight loss over 12 months than patients in the other two groups. Findings are published in the JAMA.
There is a clear relationship between obesity and the severity of COVID-19 disease, according to research presented by François Pattou, Professor of Surgery at the Faculty of Medicine of the University of Lille, and head of the Department of General and Endocrine Surgery at Lille University Hospital, France, at this year's European and International Congress on Obesity.
A study of obesity among the largest Latino populations living in New York City (NYC) has reported that the prevalence of obesity varies widely with Mexicans and Puerto Ricans much more likely to have obesity than Dominicans, Ecuadorians and Colombians.
Biomedical engineers at Duke University have shown that the efficacy of a two-pronged type 2 diabetes treatment increases when the drugs are linked by a heat-sensitive tether rather than simply concurrently administered. The combination molecule is formed by an elastin-like polypeptide (ELP) linker that forms a gel-like depot when injected under the skin, which slowly dissolves and releases the active drug over time.
Expectant mothers with obesity may hinder the development of the babies' brains as early as the second trimester, according to a new study led by researchers at NYU Grossman School of Medicine. The study linked high body mass index (BMI) to changes in two brain areas, the prefrontal cortex and anterior insula. These regions play a key role in decision-making and behaviour, with disruptions having previously been linked to attention-deficit/hyperactivity disorder (ADHD), autism and overeating.
As a person's weight increases all regions of the brain go down in activity and blood flow, according to a brain imaging study, ‘Patterns of Regional Cerebral Blood Flow as a Function of Obesity in Adults’, published in the Journal of Alzheimer's Disease.
Twenty-nine leading international partners have joined forces to establish a research consortium Stratification of Obese Phenotypes to Optimize Future Obesity Therapy (SOPHIA) with the aim of improving risk assessment of comorbidities and treatment for people with obesity. Obesity complications are common, but predicting who will develop any of the 200 known complications of obesity is extremely difficult. Moreover, there are insufficient predictors for who will respond to obesity treatments.
The childhood obesity rate may increase 2.4% or 1.27 million children if school closures to prevent the spread of the coronavirus continue into December, according to the study, ‘Projecting the impact of COVID-19 pandemic on childhood obesity in the U.S.: A microsimulation model’, published in the Journal of Sport and Health Science.
Researchers from the Open University of Catalonia and the Universitat Pompeu Fabra Department of Communication, Barcelona, Spain respectively, have performed a study based on the assumption that advertising is one of the factors that contributes to the obesogenic environment.