AstraZeneca has signed an exclusive license agreement with Shanghai-based biotech Eccogene for ECC5004, an early-stage investigational oral glucagon-like peptide 1 receptor agonist that is being developed for obesity, type 2 diabetes and other cardiometabolic diseases.
Under the terms of the deal, AstraZeneca will make an upfront payment of $185 million with the potential for nearly $1.83 billion in future clinical, regulatory and commercial milestones. Eccogene will also be eligible for tiered royalties on net product sales. In exchange for its investment, AstraZeneca will have the exclusive global rights to develop and commercialize ECC5004, except in China, where the pharma will share these rights with Eccogene.
“We believe this oral GLP-1RA molecule could offer alternatives to current injectable therapies both as a potential monotherapy as well as in combination for cardiometabolic diseases such as type-2 diabetes, as well as for obesity,” said Sharon Barr, AstraZeneca’s executive vice president of biopharmaceuticals R&D.
Designed to be taken orally once a day, ECC5004 is a small molecule agonist of the GLP-1 receptor, the activation of which stimulates the secretion of insulin in response to increasing blood glucose levels. The candidate is currently being assessed in a Phase I study in the US, data from which are “promising,” according to Barr. Preliminary data from this early-stage study point to a “differentiating clinical profile” for ECC5004, highlighting its good tolerability alongside its promising performance in terms of glucose and weight reductions.
The weight loss market is expected to grow even further in the coming years, with some analysts expecting figures to reach $100 billion, while others post forecasts of $150 billion to $200 billion.