Excess weight increased the risk of death from 22% to 91% - significantly more than previously believed - while the mortality risk of being slightly underweight has likely been overestimated, according to a study by researchers from the University of Colorado Boulder, CO. The findings counter prevailing wisdom that excess weight boosts mortality risk only in extreme cases.
The statistical analysis of nearly 18,000 people also shines a light on the pitfalls of using Body Mass Index (BMI) to study health outcomes, providing evidence that the go-to metric can potentially bias findings, according to the study authors. After accounting for those biases, it estimates that about 1 in 6 US deaths are related to excess weight.
"Existing studies have likely underestimated the mortality consequences of living in a country where cheap, unhealthy food has grown increasingly accessible and sedentary lifestyles have become the norm," said author, Dr Ryan Masters, associate professor of sociology at CU Boulder. "This study and others are beginning to expose the true toll of this public health crisis."
While numerous studies show that heart disease, high blood pressure and diabetes elevate mortality risk, very few have shown that groups with higher BMIs have higher mortality rates.
Instead, in what some call the 'obesity paradox,' most studies show a U-shaped curve: Those in the "overweight" category (BMI 25 to 30) surprisingly have the lowest mortality risk. Those in the "obese" category (30 to 35) have little or no increased risk over the so-called "healthy" category (18.5-25). And both the "underweight" (less than 18.5) and extremely obese (35 and higher) are at increased risk of death.
"The conventional wisdom is that elevated BMI generally does not raise mortality risk until you get to very high levels and that there are actually some survival benefits to being overweight," added Masters, a social demographer who has spent his career studying mortality trends. "I have been suspicious of these claims."
He noted that BMI, which doctors and scientists often use as a health measure, is based on weight and height only and doesn't account for differences in body composition or how long a person has been overweight.
"It's a reflection of stature at a point in time. That's it," said Masters, noting that Tom Cruise (at 5 feet 7 inches and an extremely muscular 201 pounds at one point), had a BMI of 31.5, famously putting him in the category of "obese." "It isn't fully capturing all of the nuances and different sizes and shapes the body comes in."
To see what happened when those nuances were considered, Masters mined the National Health and Nutrition Examination Survey (NHANES) from 1988 to 2015, looking at data from 17,784 people, including 4,468 deaths.
He discovered that a full 20% of the sample characterized as "healthy" weight had been in the overweight or obese category in the decade prior. When set apart, this group had a substantially worse health profile than those in the category whose weight had been stable.
Masters pointed out that a lifetime carrying excess weight can lead to illnesses that, paradoxically, lead to rapid weight loss. If BMI data is captured during this time, it can skew study results.
"I would argue that we have been artificially inflating the mortality risk in the low-BMI category by including those who had been high BMI and had just lost weight recently," he said.
Meanwhile, 37% of those characterized as overweight and 60% of those with obese BMI had been at lower BMIs in the decade prior. Notably, those who had only recently gained weight had better health profiles.
"The health and mortality consequences of high BMI are not like a light switch," said Masters. "There's an expanding body of work suggesting that the consequences are duration-dependent."
By including people who had spent most of their life at low-BMI weight in the high-BMI categories, previous studies have inadvertently made high BMI look less risky than it is, he said.
When he looked at differences in fat distribution within BMI categories, he also found that variations made a huge difference in reported health outcomes.
Collectively, the findings confirm that studies have been "significantly affected" by BMI-related bias. When re-crunching the numbers without these biases, he found not a U-shape but a straight upward line, with those with low BMI (18.5-22.5) having the lowest mortality risk. Contrary to previous research, the study found no significant mortality risk increases for the 'underweight' category.
While previous research estimated 2 to 3% of U.S. adult deaths were due to high BMI, his study pegs the toll at eight times that.
Masters said he hopes the research will alert scientists to be 'extremely cautious' when making conclusions based on BMI. But he also hopes that the work will draw attention to what he sees not as a problem for individuals alone to solve, but rather a public health crisis fuelled by an unhealthy or "obesogenic" environment in the US.
"For groups born in the 1970s or 1980s who have lived their whole lives in this obesogenic environment, the prospects of healthy aging into older adulthood does not look good right now," he said. "I hope this work can influence higher-level discussions about what we as a society can do about it."
The findings were reported in the paper, ‘Sources and severity of bias in estimates of the BMI–mortality association’, published in the journal, Population Studies.