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The oral GLP-1, orforglipron, can help adults with obesity and type 2 diabetes lose more weight and improve their blood sugar levels compared to a placebo, according to findings from the ATTAIN-2 trial led by researchers from the University of Texas Health Science Center at Houston, TX. Orforglipron (Image credit: Jovan.gec) "The opportunity for an oral GLP-1 medication with highly effective weight loss that is simpler to take may provide increased access and opportunities fo

A case-controlled study on the use of the Allurion Smart Capsule combined with lifestyle intervention (LI) compared to LI alone, has found a significantly higher weight reduction, fat mass loss, and visceral fat loss in patients treated with the Allurion Smart Capsule combined with lifestyle intervention. At 36 weeks, Allurion Smart Capsule patients had an average weight reduction of 20% with favourable body composition changes. The Allurion Smart Capsule is designed to be sw

Viking Therapeutics has completed patient enrolment in its Phase 3 VANQUISH-1 clinical trial of subcutaneous VK2735, the company's dual agonist of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors. VK2375 is being developed in both oral and subcutaneous formulations for the potential treatment of metabolic disorders such as obesity. The Phase 3 VANQUISH-1 study is a randomised, double-blind, placebo-controlled, multi-centre t

A research team has developed a fluorescent probe that allows scientists to visualise how individual lipid droplets break down inside living cells in real-time. The probe changes its fluorescence properties depending on the chemical composition of each droplet, which allows researchers to observe not only their location within cells, but also their metabolic activity during lipid breakdown. The findings may contribute to the development of new strategies to treat metabolic di

Obesity severity is incrementally associated with a broad range of cardiometabolic and renal disease burden, as discovered by researchers at Pennington Biomedical Research Center. In a presentation by Dr Florina Corpodean titled, ‘Associations of Obesity Severity with Cardiometabolic and Renal Disease Burden in the United States," at ObesityWeek 2025, she explored the relationship through a cross-sectional study of data from the US Behavioral Risk Factor Surveillance System s

Outcomes from the Phase 3 clinical trial of mazdutide, a first-in-class dual glucagon (GCG)/glucagon-like peptide-1 (GLP-1) receptor agonist, in Chinese adults with obesity (GLORY-2) has met the primary endpoints and all key secondary endpoints. Innovent Biologics plans to submit the new drug application (NDA) of mazdutide 9 mg for weight management to the Center for Drug Evaluation (CDE) of China's National Medical Products Administration (NMPA) in the near term. GLORY-2 is