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Obesity and stress influence appetite triggered by reward and cognitive control influences

Updated: Oct 21, 2022

In a series of experiments using functional magnetic resonance imaging (fMRI) to measure brain activity across networks in the brain, Johns Hopkins Medicine researchers looked at how stress might increase appetite in obese and lean adults. The researchers found that stress impacts the brain's responses to food, and that both lean and obese adults react to food cues in areas of the brain associated with reward and cognitive control. The findings of the study, ‘Obesity and acute stress modulate appetite and neural responses in food word reactivity task’, were published in PLOS ONE.

For the study, the researchers analysed data from 29 adults (16 women and 13 men), 17 of whom had obesity and 12 of whom were lean. Participants completed two fMRI scans, one following a combined social and physiological stress test.

Participants were given a food word reactivity test during both scans. This test involved looking at how people's brains reacted to food words, such as menu items on a chalkboard. To maximise the appetitive response in the brain, the researchers asked participants to imagine how each food looked, smelled and tasted, and how it would feel to eat it at that moment. They were also asked how much they wanted each food, and if they felt they should not eat that food, to see how they approached decision-making related to each food.

"The experiments showed that obese and lean adults differ somewhat in their brain responses, with obese adults showing less activation of cognitive control regions to food words, especially to high-calorie foods, like for example, grilled cheese," says lead researcher, Dr Susan Carnell, associate professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine.

The study also showed that stress impacts brain responses to food. For example, obese individuals showed greater activation of the orbitofrontal cortex, a brain reward region, after the stress test.

"We also found evidence for links between the subjective stress experienced and brain responses in both groups. For example, lean individuals who reported higher stress following the test showed lower activation of the dorsolateral prefrontal cortex, a key brain area for cognitive control," added Carnell.

“Taken together, our results suggest that obese adults with and without binge eating may show a pattern of greater activation in a distributed appetitive circuit including structures involved in emotion/reward, sensorimotor function, and conflict processing in response to written food words that could contribute to excessive intake and weight gain,” the authors concluded. “…Within this context of broad similarity of brain activation across conditions though, our ad libitum meal results suggested that some obese individuals may be at greater risk of overeating following stress, while our exploratory correlational analyses supported greater appetitive circuit activation with greater subjective stress responses within the obese group.”

Further information

To access this paper, please click here


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