Overeating is not the primary cause of obesity

Updated: Sep 17

Researchers from the Boston Children's Hospital and Harvard Medical School have outlined an alternative to the energy balance model, arguing that an alternate model, the carbohydrate-insulin model, better explains obesity and weight gain.

The Dietary Guidelines for Americans 2020-2025 "requires adults to reduce the number of calories they get from foods and beverages and increase the amount expended through physical activity." This approach to weight management is based on the century-old energy balance model which states that weight gain is caused by consuming more energy than we expend. Therefore, overeating coupled with insufficient physical activity, is driving the obesity epidemic. On the other hand, despite decades of public health messaging exhorting people to eat less and exercise more, rates of obesity and obesity-related diseases have steadily risen.


The authors of a new study, ‘The Carbohydrate-Insulin Model: A Physiological Perspective on the Obesity Pandemic’, published in The American Journal of Clinical Nutrition, point to fundamental flaws in the energy balance model, and claim the carbohydrate-insulin model points the way to more effective, long-lasting weight management strategies.

"During a growth spurt, for instance, adolescents may increase food intake by 1,000 calories a day,” said lead author of the study, Dr David Ludwig, Endocrinologist at Boston Children's Hospital and Professor at Harvard Medical School. “But does their overeating cause the growth spurt or does the growth spurt cause the adolescent to get hungry and overeat?"

In contrast to the energy balance model, the carbohydrate-insulin model makes a bold claim: overeating isn't the main cause of obesity. Instead, the carbohydrate-insulin model lays much of the blame for the current obesity epidemic on modern dietary patterns characterised by excessive consumption of foods with a high glycaemic load: in particular, processed, rapidly digestible carbohydrates. These foods cause hormonal responses that fundamentally change our metabolism, driving fat storage, weight gain and obesity.


When we eat highly processed carbohydrates, the body increases insulin secretion and suppresses glucagon secretion. This, in turn, signals fat cells to store more calories, leaving fewer calories available to fuel muscles and other metabolically active tissues. The brain perceives that the body is not getting enough energy, which, in turn, leads to feelings of hunger. In addition, metabolism may slow down in the body's attempt to conserve fuel. Thus, we tend to remain hungry, even as we continue to gain excess fat.


According to the researchers, to understand the obesity epidemic, we need to consider not only how much we are eating, but also how the foods we eat affect our hormones and metabolism. With its assertion that all calories are alike to the body, the energy balance model misses this critical piece of the puzzle.


They study, authored by a team of 17 internationally recognized scientists, clinical researchers and public health experts, summarises the growing body of evidence in support of the carbohydrate-insulin model. Moreover, the authors have identified a series of testable hypotheses that distinguish the two models to guide future research.


Adoption of the carbohydrate-insulin model over the energy-balance model has radical implications for weight management and obesity treatment. Rather than urge people to eat less, a strategy which usually doesn't work in the long run, the carbohydrate-insulin model suggests another path that focuses more on what we eat.

“Reducing consumption of the rapidly digestible carbohydrates that flooded the food supply during the low-fat diet era lessens the underlying drive to store body fat. As a result, people may lose weight with less hunger and struggle,” added Ludwig.

The authors acknowledge that further research is needed to conclusively test both models and, perhaps, to generate new models that better fit the evidence. Toward this end, they call for constructive discourse and "collaborations among scientists with diverse viewpoints to test predictions in rigorous and unbiased research."


Further Information

Access the research paper here