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Roche enters weight loss and metabolic market with Carmot Therapeutics acquisition

Roche has completed its acquisition of Carmot Therapeutics, which includes Carmot’s R&D portfolio including all clinical and pre-clinical assets, as well as exclusive access to Carmot’s innovative Chemotype Evolution discovery platform in metabolism, further strengthening Roche’s R&D efforts and portfolio across cardiovascular and metabolic diseases. Carmot and its employees will join the Roche Group as part of Roche’s Pharmaceuticals Division.

The acquisition gives Roche access to Carmot’s differentiated portfolio of incretins including:

  • CT-388, the lead asset, is a Phase-2 ready, dual GLP-1/GIP receptor agonist for the treatment of obesity in patients with and without type 2 diabetes. Injected subcutaneously once a week, it has potential as a standalone and combination therapy to improve weight loss and to be expanded to other indications.

  • CT-996, a once-daily oral, small molecule GLP-1 receptor agonist currently in Phase-1 intended to treat obesity in patients with and without type 2 diabetes.

  • CT-868, a Phase-2, once-daily subcutaneous injectable, dual GLP-1/GIP receptor agonist intended for the treatment of type 1 diabetes patients with overweight or obesity.


Roche acquired all outstanding shares and options of Carmot at a purchase price of US$2.7 billion. Carmot’s equity holders are additionally entitled to receive payments of up to US$400 million depending on the achievement of certain milestones.

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