The type of bariatric surgery women undergo before becoming pregnant may affect how much weight their children gain in the first three years of life, according to a study by Columbia University Irving Medical Center (CUIMC) researchers presented at ENDO 2024, the Endocrine Society's annual meeting in Boston, MA.
Researchers found children born to women who underwent a sleeve gastrectomy before they became pregnant gain more weight per month on average in the first three years of life compared with children born to women who had a Roux-en-Y gastric bypass.
"Either the extent of pre-pregnancy weight loss or the metabolic changes from Roux-en-Y gastric bypass may be favourable for the children's early childhood weight gain," said researcher, Dr Vidhu Thaker, from CUIMC.
In the study, researchers examined the weight and length of offspring born after pre-pregnancy weight loss procedures in the first three years of life. The study used data from 20,515 deliveries over three years, of which 450 had pre-pregnancy bariatric surgery. Among the mothers who underwent surgery, 57% had sleeve gastrectomy and 41% had Roux-en-Y gastric bypass. Long-term weight and length data were available for about half of the babies in each group.
The researchers found there was no difference in birth weight among the babies born after weight loss surgery. The pace of weight gain was higher in those born after pre-pregnancy sleeve gastrectomy compared to those born following Roux-en-Y gastric bypass, while adjusting for several other variables including pre-pregnancy body mass index.
The authors concluded that either the extent of pre-pregnancy weight loss or the metabolic changes from Roux-en-Y gastric bypass may be favourable for the offspring's early childhood weight trajectory.
"While we did not have data on the magnitude of weight loss following bariatric surgery, Roux-en-Y gastric bypass is known to have higher weight loss and metabolic changes compared to sleeve gastrectomy," Thaker noted. "A study of the mechanisms underlying the associations of the sustained pre-pregnancy weight loss and the offspring's early life growth may also apply to other methods of weight loss, including the most recently approved anti-obesity medications.”