EBWMP plus anti-obesity medications results in greater weight loss

Updated: Aug 3

A Cleveland Clinic study has reported that adults with obesity lost significantly more weight when they had access to medications for chronic weight management in conjunction with their employer-based weight management programme (EBWMP), compared to adults who did not have access to the medications. The study, ‘Effectiveness of Combining Antiobesity Medication With an Employer-Based Weight Management Program for Treatment of Obesity’, was published in JAMA Network Open. The estimated medical care costs of obesity in the US represented US$147 billion (in 2008 dollars).

"The research results support the need to treat patients with a multidisciplinary weight management program that incorporates safe and effective medications to lose weight and maintain weight loss," said Dr Bartolome Burguera, chair of Cleveland Clinic's Endocrinology & Metabolism Institute and primary investigator of the study. "Doctors prescribe medications to treat some of the health consequences associated with obesity, such as hypertension and type 2 diabetes. However, medications for weight loss and chronic weight management are underutilised."


The objective of this study was to determine the effect of combining anti-obesity medications with a multidisciplinary employer-based weight management programme. The one-year, single-centre, pragmatic clinical trial was conducted in the real-world setting of a workplace health plan. The study included 200 adults with obesity (BMI>30) who were enrolled in the Cleveland Clinic Employee Health Plan between January 2019 and May 2020. As part of the health plan, participants had access to a comprehensive weight management programme.

In this real-world setting, eligible participants were randomised 1:1 to either a weight management program with FDA-approved anti-obesity medications or a weight management programme alone. The weight management programme was administered through monthly shared medical appointments (SMAs) that offered a multidisciplinary approach, including nutrition education. The monthly SMA visits focused on adopting a healthier lifestyle and addressed the five components of the weight management programme: nutrition, physical activity, appetite control, sleep and mental health. Due to the COVID-19 pandemic, some of the SMAs were conducted virtually.

The 100 study participants, randomised to the weight management programme combined with access to the medications, received their prescriptions at the time of their monthly SMAs, based on recommended clinical practice.

Patients were prescribed one of five FDA-approved medications for chronic weight management—orlistat, lorcaserin, phentermine/topiramate, naltrexone/bupropion, liraglutide 3.0mg. The medication selected for each patient was at the discretion of the treating provider and was determined after a thorough assessment and discussion with the participants. Lorcaserin was withdrawn from the market in February 2020 and the eight patients taking lorcaserin at the time were notified immediately and either switched medications or discontinued medication due to proximity to the end of the study.

Research results showed that the participants who had access to the anti-obesity medications averaged significantly greater weight loss at 12 months (-7.7%), compared to the participants who were in the weight management programme alone (-4.2%). In the group who had access to the medications, 62.5% of the participants lost at least 5% of their weight, compared to 44.8% of the participants in the group with the weight management programme alone. SMA attendance was higher among the participants who had access to the weight loss medications.

"Many patients see improvement in their health when they lose 5% of their weight," said Dr Kevin M Pantalone, first author of the study and an endocrinologist at Cleveland Clinic. "Based on our study results, access to anti-obesity medications combined with a multidisciplinary weight management program provides a more effective treatment compared to a weight management program without access to these medications."

More long-term research is needed in real-world, employer-based settings to evaluate the costs and benefits of anti-obesity medications and their use in conjunction with workplace wellness plans.

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