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Negative effects from obesity caused by body’s loss of plasticity

The negative health effects of obesity stem not simply from an excess of fat but from the decline in body’s ability to respond to changes, or in other words, its plasticity. Writing in the paper, ‘Adipose tissue plasticity in health and disease’, published in Cell, they noted that obesity is known to cause cardiometabolic diseases like hypertension and diabetes but attributing these diseases to merely an overabundance of fat is a simplification.

The hallmarks of adipose tissue dysfunction. Credit Sakers et al.Cell

On a basic level, adipose tissue acts as a receptacle to store energy, but upon a closer look it is an essential actor in vital bodily processes like the immune response, the regulation of insulin sensitivity, and maintenance of body temperature.

The makeup and functioning of this tissue changes in response to weight fluctuations and aging. As fat declines in plasticity due to aging and obesity, it loses its ability to respond to bodily cues. In the current model of this phenomenon, the rapid growth of adipose tissue outpaces its blood supply, depriving the fat cells of oxygen and causing the accumulation of cells that no longer divide. This leads to insulin resistance, inflammation, and cell death accompanied by the uncontrolled spill of lipids from these cells.

The researchers stated that adipose tissue lies at the centre of these health problems, primarily in the:

  • Rapid titration of metabolic programs to maintain systemic energy levels in the face of fluctuating changes in nutrient supply and demand

  • Unparalleled capacity to expand and contract to accommodate long-term trends in energy balance

  • Remarkable structural and metabolic transformation during cold exposure to engage in heat production; and

  • Capacity for dedifferentiation to regulate lactation and wound healing.

"The central role of adipose tissue dysfunction in disease and the incredible plasticity of fat tissue supports the promise of modulating fat tissue phenotypes for therapeutic purposes," write the authors, led by Dr Claudio J Villanueva from the College of Life Sciences/David Geffen School of Medicine and Patrick Seale from Perelman School of Medicine at the University of Pennsylvania. "Many questions and opportunities for future discovery remain, which will yield new insights into adipose tissue biology and hopefully lead to improved therapies for human disease."

To access this paper, please click here


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