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News about clinical research: trials, studies, case reports, etc.

Patients report improvements in anxiety and depression after SG

A majority of patients who had a sleeve gastrectomy (SG) reported an improvement in anxiety and depression, according to a study by researchers from the University at Buffalo. The investigators noted that anti-depressant and anti-anxiety medication regimens were altered in approximately one-third of cases and were primarily dose decrease or discontinuation, and where symptoms improved the medications were decreased or discontinued in over 90%.

Latino men in the US more susceptible to obesity

Moving to the US could be taking a toll on the health of Latino men as a new study from Florida State University reported Latino men who are born or live in the US for more than five years are more susceptible to obesity.  The study, led by Professor Amy Ai, found US born Latino men were more than twice as likely to be obese than those born outside the US and that could be a problem for the nation's workforce.

3D imaging technique tracks satiety hormone Leptin

Many overweight people lack the feeling of being full and it was believed that this was due to the disrupted transport of the satiety hormone leptin to the brain. However, a group of scientists from Helmholtz Zentrum München, Germany, have now shown with a new 3D imaging technique – which allows tracking the path of the hormone in the brain – that this is not the case.

Time spent online by children linked to requests for junk food

Young children who spent more than half an hour a day online were almost twice as likely to pester their parents for junk food, according to a report published by researchers from the University of Liverpool and Cancer Research UK's Cancer Policy Research Centre. The study, which examines the associations between diet and advertising of junk food on TV and the internet, questioned children and their parents in the North West and across the UK.

Children with obesity do not have more pain after surgery

While adults who have obesity often report more pain after surgery, the same does not appear to be true for children with obesity, according to the largest study of its kind, presented at the Anesthesiology 2018 annual meeting. The findings suggest the current protocol for managing pain in children after surgery - in which dosing is based on the patient's actual body weight, and not BMI or whether the child is considered to have obesity - should continue.

Amount of weight regain after surgery can predict health risks

Measuring the percentage of weight regained following the maximum amount of weight lost after bariatric surgery can help predict a patient's risk of several serious health problems, according to a long-term, multi-centre study led by University of Pittsburgh Graduate School of Public Health researchers. The results also found that while on average study participants achieved maximum weight loss at two years post-surgery, when they reached that milestone the outcomes varied substantially with approximately 20 percent continuing to lose weight more than four years post-surgery.

Surgery reduces macrovascular events in T2DM patients

People with T2DM and severe obesity who had bariatric surgery were 40 percent less likely to have a heart attack or stroke within five years than those who had usual medical care for their diabetes, according to a study at four systems in the Health Care Systems Research Network. During the same period, those who had surgery were also more than one-third less likely to develop heart disease and two-thirds less likely to die from any cause.

Alcohol screening tests fail to work in RYGB patients

People who undergo Roux-en-Y gastric bypass (RYGB) surgery are at increased risk for alcohol-related problems and common screening tools that help physicians identify patients at high risk for alcohol use disorder fail to work well in this population, according to a long-term, multi-centre analysis led by University of Pittsburgh Graduate School of Public Health scientists.

Women with obesity linked with increased risk of early-onset CRC

Women who are overweight or have obesity have up to twice the risk of developing colorectal cancer (CRC) before age 50 as women who have what is considered a ‘normal’ BMI, according to new research led by Washington University School of Medicine in St Louis.

LNC Therapeutics launches OBEMINALE 2 clinical trial

LNC Therapeutics, a French biotech company specialized in the gut microbiome-based drug discovery, has announced the launch of a new clinical trial with Stablor, OBEMINALE 2, and the treatment of the first patient. This new clinical study is intended to obtain 13.5 health claim from the European Food Safety Authority, EFSA. The final results are expected in the fourth quarter of 2019.

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