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Research

News about clinical research: trials, studies, case reports, etc.

Rheumatic disorders improved post-op risk of fractures increased

A literature review by researchers looking at the complex relationship between obesity, various rheumatic diseases and bariatric surgery has underscored the need to establish long-term prospective controlled trials evaluate the risk-benefit ratio of bariatric surgery in patients with morbid obesity and rheumatic diseases.

Cognitive functioning not a predictor of weight-loss for adolescents

Young people with cognitive impairments and developmental disabilities (CI/DD), including Down syndrome, have similar weight-loss trajectories to those with typical cognitive function after bariatric surgery, according to a study by psychologists at Children's National Health System, Washington DC.

Kuwait publishes 1st National Bariatric Registry Report

The State of Kuwait Ministry of Health and Dendrite Clinical Systems, in conjunction with Bader Sultan & Brothers Company, are delighted to announce the publication of the First Kuwait National Bariatric Registry Report 2019, the first ever national report on bariatric and metabolic surgery in the Arabian Gulf region. This inaugural report, which includes 3,302 bariatric surgery cases, contains data on baseline obesity-related disease, operation types, operative outcomes and disease status after bariatric surgery in Kuwait.

RYGB offers better weight loss but higher readmission rates vs LSG

One-year outcomes from over 47,000 Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy procedures has reported that RYGB resulted in a higher rate of patients with total weight loss (TWL) >20% (95.8% vs 84.6%, p<0.001). However, there were no significant differences between the two procedures in the rate of severe complications (2.6% vs 2.4%, p=0.382) and 30-day mortality (0.04% vs 0.03%, p=0.821), although readmission rates were higher post-RYGB (4.3% vs 3.4%, p<0.001).

Insulin receptor and gene expression leads to new research

Researchers from Harvard Medical School have made key new insights into the molecular behaviour of insulin via an unexpected mechanism by which insulin triggers changes to the expression of thousands of genes throughout the genome. Their analyses show that the insulin receptor - a protein complex at the cell surface - physically transports to the cell nucleus after it detects and binds insulin. Once there, it helps initiate the expression of genes involved in insulin-related functions and diseases. This process was impaired in mice with insulin resistance.

Patient behaviours associated with post-surgery weight regain

In the years following bariatric surgery, a person's overall eating behaviours and the amount of time spent watching television, playing video games and using a computer for recreation are a better indication of long-term weight loss success than specific weight control practices like counting calories, according to findings by the University of Pittsburgh Graduate School of Public Health.

Gelesis data shows hydrogel restores gut barrier function

Gelesis has announced clinical data from its pivotal Gelesis Loss of Weight (GLOW) study suggesting that elevated fasting plasma glucose could be a useful and unique predictor to identify individuals who have higher adjusted odds to achieve significant weight loss with Gelesis100.

LINX Reflux System reduces costs vs. laparoscopic Nissen fundoplication

Treatment with the LINX Reflux Management System reduced medical costs more than laparoscopic Nissen fundoplication (LNF), a more invasive anti-reflux surgery, and more than offsets the slightly higher cost of the procedure, according to a study presented at the 2019 Annual Meeting of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES 2019). The research was partially funded by Ethicon, in collaboration with Highmark Health’s VITAL Innovation Platform, a test-and-learn environment for health innovations.

Bariatric embolization shows promise as a treatment for obesity

Although bariatric embolization is unlikely to promote weight loss as effectively as bariatric surgery, it is at least as effective as some pharmacotherapies (ie, liraglutide, orlistat, lorcaserin), which induce mean weight loss of 2%–9% (28), according to researchers from the Bariatric Embolization of Arteries for the Treatment of Obesity (BEAT Obesity) trial, who assessed the procedure's effects on 20 severely obese participants over the course of one year.

First patients implanted with ReShape Vest in ENDURE II Trial

ReShape Lifesciences announced that the company has successfully implanted its first patient in the ENDURE II trial designed to support CE Marking of the ReShape Vest. The ReShape Vest System is an investigational, minimally invasive, laparoscopically implanted medical device that wraps around the stomach, emulating the gastric volume reduction effect of conventional weight-loss surgery, and is intended to enable rapid weight loss in obese and morbidly obese patients without permanently changing patient anatomy.

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