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Study identifies genetic predictors for GLP-1 weight loss efficacy and side effects A large-scale genome-wide association study (GWAS) has identified genetic predictors for GLP-1 weight loss efficacy and side effects. The findings provide direct evidence that variation in the genes targeted by GLP-1 medications contributes to why people respond differently to GLP-1 therapies. Illustration of the biological pathways for the GLP-1 genetic associations identified by the 23andMe