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Inconsistent use of some GLP-1 weight-loss medications, like Ozempic and Wegovy, may significantly lessen their effectiveness, according to a preclinical study from researchers at the Perelman School of Medicine at the University of Pennsylvania. The study showed that each time overweight mice stopped and restarted GLP-1s, they dropped less and less weight compared their original weight-loss. “The effectiveness of these medications may depend heavily on consistency,” said Dr