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A global panel of 21 obesity and cancer experts have suggested that to test the potential efficacy of the new generation of obesity drugs such as semaglutide and tirzepatide in preventing obesity-related cancer (ORC), a trial of the drugs for some 5,000 participants at high risk of cancer due to their having a cancer pre-cursor condition will provide the required answers. The group of experts, convened at the European Congress on Obesity (ECO2026) in Istanbul, Turkey, includi