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Researchers decipher mechanism preventing the loss of brown adipose tissue activity during ageing

A study led by the University of Barcelona has identified a key molecular mechanism in the loss of brown fat activity during ageing. The study opens up new perspectives for designing strategies to boost the activity of this tissue and prevent chronic metabolic and cardiovascular diseases as the population ages. From left to right, Tania Quesada-López, Francesc Villarroya, Albert Blasco-Roset, Marta Giralt, Alberto Mestres-Arenas, Joan Villarroya, Aleix Gavaldà-Navarro and Rub

CagriSema associated with significant reduction in blood pressure and reduces the proportion of patients at risk of developing heart disease

Post hoc analyses from the phase 3 REDEFINE 1 trial evaluating CagriSema, an investigational injectable combination treatment for adults with overweight or obesity, and its effects on well-known cardiovascular (CV) risk factors, has revealed that systolic blood pressure was reduced by -10.9 mmHg over 68 weeks (versus -8.8 mmHg with semaglutide 2.4 mg and -2.1 mmHg with placebo). This reduction was seen regardless of BMI (less than versus greater than or equal to 35 kg/m2). In

Lilly and US government agree to expand access to obesity medicines

Eli Lilly and Company has announced an agreement with the US government to expand access to its obesity medicines and reduce patient costs. In 2020, Lilly partnered with the Trump Administration on a pilot programme that paved the way for Lilly to be the first company to cap out-of-pocket insulin costs at $35 per month. Lilly will now improve access to nearly 40 million Americans living with obesity on government insurance programmes and millions more who pay out-of-pocket. U

Nitinotes gains CE Mark approval for EndoZip fully automated suturing system for ESG

Nitinotes has received CE Mark approval for the EndoZip System, the first fully automated suturing platform for endoscopic sleeve gastroplasty (ESG). The milestone clearance enables the company to begin commercialisation across the European Union and other CE Mark-accepting markets. Nitinotes will launch EndoZip in select European centres of excellence, building clinical adoption and real-world data to support broader market penetration. In parallel, the company is preparing

Nutrient warning labels could prevent 100,000+ obesity-related deaths

Researchers from the University of Liverpool, using the first modelled estimate to date shows how mandatory nutrition labelling could impact obesity prevalence and mortality in England's population, have found that making front-of-pack nutrition labelling mandatory could significantly reduce obesity rates and save thousands of lives across England. Using a microsimulation model, the team examined the effects of introducing either mandatory traffic light or nutrient warning la

OMMs appear to be valid alternatives to EBP and MBS for mild-to-moderate obesity, but surgery more effective for patients with a higher degree of obesity

For patients living with mild-to-moderate obesity, newer obesity management medications (OMM) such as tirzepatide and semaglutide, appear to be valid alternatives to endoscopic bariatric procedures (EBP) and metabolic bariatric surgery (MBS), according to researchers from the Italian Obesity Society (Società Italiana dell'Obesità (SIO)). Their study reveals the results from a systematic review (SR) and a network meta-analysis (NMA) on randomised clinical trials (RCTs) compari