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A brain-computer interface reveals the tirzepatide has a short-term or incomplete effect on related brain activity in a patient with obesity, calling for further study, a study by University of Pennsylvania School of Medicine has found. The nucleus accumbens on a brain CT of a patient (Credit: Penn Medicine) The research suggests that the medication, a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, may be able to treat

The combination of a loose fundoplication utilising the excluded stomach into one-anastomosis gastric bypass (OAGB) demonstrates a notable enhancement in HRQoL compared with OAGB alone, for patients experiencing obesity and significant reflux. According to the study’s authors by researchers from Homerton University Hospital, London and Ain Shams University, Cairo, this combined approach yielded lower GERD-Health-Related Quality of Life (GERD-HRQL) scores (indicating improved

New research from Saint Louis University School of Medicine and SSM Health has revealed weight loss medications could help dialysis patients qualify for kidney transplants. The study is among the largest to examine semaglutide in dialysis patients. These individuals are often excluded from transplant waitlists because a high body mass index (BMI) increases surgical risks and impacts outcomes after transplantation. Key findings: Patients lost an average of 20.5 pounds after on

Vanda Pharmaceuticals has announced positive topline results from its randomised controlled clinical study (VP-VLY-686-2601) evaluating tradipitant, an oral neurokinin-1 (NK-1) receptor antagonist, for the prevention of nausea and vomiting induced by GLP-1 receptor agonist Wegovy in overweight and obese adults. This study, which pre-treated patients with either tradipitant or placebo before administering a 1 mg injection of Wegovy, a dose that normally takes 9 weeks of titrat

In a large retrospective study using the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database, conversional bariatric surgery seems to be increasing in incidence in adults under 40, with notable differences in baseline characteristics of patients undergoing different conversional procedures as well as the reasons for conversion. The study, carried out by researchers from the University of Alberta, Edmonton, Alberta, Canada, to under

The rate of children and adolescents experiencing high blood pressure worldwide nearly doubled between 2000 and 2020, according to a new meta-analysis by researchers from China and the UK. In 2000, approximately 3.2% of children had hypertension, but by 2020, the prevalence had increased to more than 6.2% of children and adolescents under age 19, affecting 114 million young people around the world. The study suggests that obesity is a substantial driver of the increase in chi