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A systematic review and meta-analysis has indicated that bariatric surgery may reduce the overall risk of breast cancer in women with obesity, according to researchers from China. However, the studies also revealed a paradoxical finding: Despite the overall reduction in risk, the incidence of stage I breast cancer increased in the surgical group. Nevertheless, the study authors acknowledge that as the studies are based on observational data, a causal relationship cannot be co

Study identifies genetic predictors for GLP-1 weight loss efficacy and side effects A large-scale genome-wide association study (GWAS) has identified genetic predictors for GLP-1 weight loss efficacy and side effects. The findings provide direct evidence that variation in the genes targeted by GLP-1 medications contributes to why people respond differently to GLP-1 therapies. Illustration of the biological pathways for the GLP-1 genetic associations identified by the 23andMe

A collaboration between the University of Maryland (UMD) and University of Concepción in Chile has uncovered a communication chain in the brain. The research identified a previously unknown communication chain in the hypothalamus - the region of the brain responsible for regulating hunger and fullness - these findings could eventually point to new ways of targeting appetite-related conditions such as obesity and eating disorders. Brain regulation of appetite. Diagram showing

The FDA has approved Eli Lilly and Company’s Foundayo (orforglipron) for adults with obesity or overweight with weight-related medical problems. Foundayo is a once-daily small molecule (non-peptide) oral glucagon-like peptide-1 receptor agonist (GLP-1ra) that can be taken any time of the day without restrictions on food and water intake. "People living with obesity need treatment options that meet them where they are – and for many, a once-daily pill that can be taken with n

Researchers in France have identified a significant shift in the country towards more complex and potentially more morbid types of revisional metabolic bariatric surgeries (RMBS), underscoring the need of careful patient selection through preoperative assessment and personalised postoperative management to reduce risks and optimise outcomes in this population. The aim of their observational study was to assess the rate of RMBS in France and to outline the associated complicati

Scientists at City of Hope and TGen (part of City of Hope) have explained a major mechanism for why gaining excess weight increases the risk of cancer across multiple organs. The findings emphasise the importance of maintaining a healthy weight from early childhood and propose a potentially more accurate way than body mass index (BMI) to predict the increase in cancer risk associated with obesity. "People have long been told that obesity increases cancer risk, but they are ra