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For decades, scientists have known that what harms the body often harms the brain. Conditions such as obesity, high blood pressure and insulin resistance strain the body's vascular and metabolic systems. Over time, that stress can speed up cognitive decline and increase the risk of Alzheimer's disease. Now, researchers at Arizona State University and their collaborators report that these effects may begin far earlier than expected. This graphic shows how obesity in young adul

A study conducted at Harvard University has identified a group of metabolites that travel from the intestine to the liver and then to the heart, where they are pumped throughout the body. These metabolites play an important role in controlling metabolic pathways in the liver and insulin sensitivity. This discovery may contribute to future treatments for obesity and type 2 diabetes. Diagram summarising the experiments, which analyzed metabolites present in the peripheral blood

Soybean oil, the most widely consumed cooking oil in the US and a staple of processed foods, contributes to obesity, at least in mice, through a mechanism scientists are now beginning to understand. Soybean oil consumption has increased alongside obesity in the US (Credit: Sonia Deol/UCR) In an experiment conducted at University of California - Riverside, most mice on a high-fat diet rich in soybean oil gained significant weight. However, a group of genetically engineered mic

Novo Nordisk announced the submission of a sNDA to the FDA for a higher dose of semaglutide injection 7.2 mg, to be used along with a reduced calorie diet and increased physical activity for chronic weight management in adults with obesity. Under the CNPV expedited program, review is expected within 1–2 months following the FDA's acceptance of the filing. The sNDA includes results from STEP UP, a 72-week phase 3, randomised, double-blind, placebo-controlled and active-control

Welcome to our regular round-up of the latest bariatric and obesity-related papers published in the medical literature. As ever, we have looked far and wide to give you an overview of papers including side-to-side compression anastomosis, surgery and mortality and kidney transplants, Indian surgeons’ perspectives on obesity, and obesity-associated vs overall deaths, and more (please note, log-in maybe required to access the full paper). Creation of Side-to-Side Compression An

The magnitude and composition of post- metabolic-bariatric surgery (MBS) weight loss were not associated with incident major adverse cardiovascular events (MACE) and mortality in the total population, according to an international team of researchers. They also reported that a high total weight loss and a disproportional composition of weight loss with a relatively high fat-free mass loss, were associated with a greater risk of adverse outcomes in middle-aged and older patien