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Researchers at the University of Utah have uncovered an enzyme, PapB, that can ‘tie off’ therapeutic peptide into tight rings, a process known as macrocyclisation. This enzymatic trick could help drug developers make stronger, longer-lasting versions of GLP-1 medications. Graphic illustrates the PapB enzyme that ties off peptides (Credit: American Chemical Society and University of Utah) Creating cyclic peptides is valuable because these ring structures make drugs more stable