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Ascletis Pharma has completed enrolment in the US Phase IIa study for its once-monthly subcutaneous (SQ) depot formulation (treatment formulation) of small molecule GLP-1 receptor (GLP-1R) agonist ASC30 for the treatment of obesity. All 65 participants are obese or overweight with at least one weight-related comorbidity. The Phase IIa study of ASC30 once-monthly SQ depot treatment formulation is a 12-week, randomised, double-blind, placebo-controlled and multi-centre study co

Novo Nordisk has received FDA approval for Rybelsus for reducing the risk of major adverse cardiovascular events (MACE) such as cardiovascular (CV) death, heart attack, or stroke in adults with type 2 diabetes who are at high risk for these events, whether they've had a prior CV event or not (primary and secondary prevention). Results of the SOUL trial reinforce the clinical profile of the semaglutide molecule, which has been studied across a variety of therapeutic areas. "Ev

The global anti-obesity drug market is estimated to increase in valve to $25.87 billion in 2025 and is expected to reach $82.55 billion by 2032, exhibiting a compound annual growth rate (CAGR) of 18.01% from 2025 to 2032.  This strong market growth is driven by the rising global prevalence of obesity and the increasing demand for effective pharmaceutical treatments, according to a re[ort by According to Coherent Market Insights (CMI). Additionally, advancements in drug formul

A patient’s decision to undergo bariatric surgery is often driven by a combination of complex factors such as health concerns, impaired quality of life and societal pressure, according to researchers from the University College Cork, Cork, Ireland. They found that health concerns were the primary motivator, with participants seeking to address comorbidities, mitigate health risks, and enhance their quality of life. In addition, body image, psychological well-being, and resist

Blood tests taken before bariatric surgery were associated with blood pressure readings five years later, according to a study from the Keck School of Medicine of USC and Ann & Robert H Lurie Children’s Hospital of Chicago. A USC-led team has developed an innovative way to predict blood pressure outcomes after bariatric surgery that outperforms the current standard practice. In 108 adolescents who underwent bariatric surgery, the researchers used blood tests taken before the

Issue 56 of Bariatric News is now available to read and/or download. In this issue, we report gastric bypass associated with a lower incidence of MACE vs. sleeve gastrectomy over an 11-year follow-up, and the world’s first transcontinental bariatric robotic procedure. We also highlight a symposia from the IFSO-EC Congress that examined the considerations when moving from laparoscopic to robotic-assisted bariatric surgery, and have an exclusive interview with Mr Ahmed Ahmed ab

Researchers at the University of Utah have uncovered an enzyme, PapB, that can ‘tie off’ therapeutic peptide into tight rings, a process known as macrocyclisation. This enzymatic trick could help drug developers make stronger, longer-lasting versions of GLP-1 medications. Graphic illustrates the PapB enzyme that ties off peptides (Credit: American Chemical Society and University of Utah) Creating cyclic peptides is valuable because these ring structures make drugs more stable

Nineteen states had adult obesity rates at or above 35 percent in 2024, down from 23 states in 2023 (Figures 1 and 2), a first time decrease in the number of states at or above the 35 percent level for this dataset. The findings were featured in the ‘State of Obesity 2025: Better Policies for a Healthier America’, released by Trust for America’s Health (TFAH), a non-partisan, non-profit organization focused on public health research and policy. Figure 1: Adult Obesity Rate by

The prevalence of obesity in the US could rise sharply under a new definition of obesity released earlier this year by the Lancet Diabetes and Endocrinology Commission . Researchers from Mass General Brigham found that when applying the new criteria, which expands upon the traditional use of body mass index (BMI) to include measures of body fat distribution, the prevalence of obesity increased from about 40 percent to about 70 percent among over 300,000 people included in the

Welcome to our regular round-up of the latest bariatric and obesity-related papers published in the medical literature. As ever, we have looked far and wide to give you an overview of papers including dumping syndrome post-OAGB, the economic impact of bariatric surgery, boredom and stress as predictors of loss of control eating after surgery, increased physical activity associated with greater fat mass loss following MBS, MBSAQIP risk/benefit calculator predicting weight loss