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Researchers at the University of Utah have uncovered an enzyme, PapB, that can ‘tie off’ therapeutic peptide into tight rings, a process known as macrocyclisation. This enzymatic trick could help drug developers make stronger, longer-lasting versions of GLP-1 medications. Graphic illustrates the PapB enzyme that ties off peptides (Credit: American Chemical Society and University of Utah) Creating cyclic peptides is valuable because these ring structures make drugs more stable

The growing use of GLP-1 receptor agonists may affect the interpretation of oncological FDG PET-CT scans, according to research presented at the 38th Annual Congress of the European Association of Nuclear Medicine (EANM'25). GLP-1 receptor agonists are now widely prescribed for individuals with type 2 diabetes and weight loss, with a 700% increase in usage reported in the US between 2019 and 2023. These medications alter glucose metabolism, gastric motility and sympathetic to

Welcome to our regular round-up of the latest bariatric and obesity-related papers published in the medical literature. As ever, we have...

As Australia faces a turning point in obesity management, researchers from Monash University have contributed new insights into the...

The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) is reviewing data on the risk of suicidal...

Scientists from Hyderabad, India, have shown that adding an experimental cancer drug to a widely used diabetes treatment improves blood...