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Vanda Pharmaceuticals has announced positive topline results from its randomised controlled clinical study (VP-VLY-686-2601) evaluating tradipitant, an oral neurokinin-1 (NK-1) receptor antagonist, for the prevention of nausea and vomiting induced by GLP-1 receptor agonist Wegovy in overweight and obese adults. This study, which pre-treated patients with either tradipitant or placebo before administering a 1 mg injection of Wegovy, a dose that normally takes 9 weeks of titrat

In a large retrospective study using the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database, conversional bariatric surgery seems to be increasing in incidence in adults under 40, with notable differences in baseline characteristics of patients undergoing different conversional procedures as well as the reasons for conversion. The study, carried out by researchers from the University of Alberta, Edmonton, Alberta, Canada, to under

The rate of children and adolescents experiencing high blood pressure worldwide nearly doubled between 2000 and 2020, according to a new meta-analysis by researchers from China and the UK. In 2000, approximately 3.2% of children had hypertension, but by 2020, the prevalence had increased to more than 6.2% of children and adolescents under age 19, affecting 114 million young people around the world. The study suggests that obesity is a substantial driver of the increase in chi

Researchers at the Keck School of Medicine of USC have completed one of the first studies to examine the link between ultra-processed foods (UPFs) consumption and how the body processes glucose, which is known to predict diabetes risk. By tracking changes over time, they gained insights into how dietary choices may influence key biological processes. More than half of calories consumed in the United States come from UPFs, items like fast food and packaged snacks that are ofte

Welcome to our regular round-up of the latest bariatric and obesity-related papers published in the medical literature. As ever, we have looked far and wide to give you an overview of papers including effectiveness of SG and OAGB on CVD risk, liraglutide plus MBS, global variations in MBS (the PARTNER Study), safety of robotic vs. laparoscopic MBS and preexisting GERD with thirty-day intervention following SG, and more (please note, log-in maybe required to access the full pa

A study by researchers from the University of California San Diego has revealed compelling evidence that glucagon-like peptide-1 (GLP-1) receptor agonists may do more than regulate blood sugar and weight. In an analysis of more than 6,800 colon cancer patients across all University of California Health sites, researchers found that those taking GLP-1 medications were less than half as likely to die within five years, compared to those who weren't on the drugs (15.5% versus 37

Implanting a silicone ring (MiniMizer Ring, Bariatric Solutions) and pouch resizing offer an effective therapeutic strategy for symptom control in patients with dumping syndrome (DS) and post-bariatric surgery hypoglycemia (PBH) independent of effects on glycaemic dynamics, according to the results of a prospective single-arm trial by researchers from the University of Freiburg, Freiburg, Germany. However, they cautioned that complete resolution of dumping symptoms is only po

Combining bariatric surgery with the weight loss medication liraglutide can help people who need to lose more weight post-metabolic bariatric surgery (MBS), Monash University and Alfred Health-led research has found. Wendy Brown "We have shown that for people who regain weight or don't have an optimal weight loss effect from bariatric surgery, adding in a weight loss drug will help them to lose weight, often at a lower dose than is needed in people who have not had surgery,"

In a major new study, researchers from Intermountain Health in Salt Lake City have found that GLP-1 receptor agonists used by patients who have high triglycerides do not increase their risk of pancreatitis or adverse cardiac events, and for those who have never had pancreatitis, being on a GLP1RA medication led to a four times lower risk of developing the condition. "Pancreatitis is incredibly painful and can be deadly. Once you have a patient with acute pancreatitis, you wan

A study led by the University of Barcelona has identified a key molecular mechanism in the loss of brown fat activity during ageing. The study opens up new perspectives for designing strategies to boost the activity of this tissue and prevent chronic metabolic and cardiovascular diseases as the population ages. From left to right, Tania Quesada-López, Francesc Villarroya, Albert Blasco-Roset, Marta Giralt, Alberto Mestres-Arenas, Joan Villarroya, Aleix Gavaldà-Navarro and Rub